3534-50-7

Basic information

• Product Name: 3,5,6-TRIFLUORO-PYRIDIN-2-YLAMINE
• Synonyms: 3,5,6-TRIFLUORO-PYRIDIN-2-YLAMINE;3,5,6-trifluoropyridin-2-aMine
• CAS NO: 3534-50-7
• Molecular Formula: C₅H₃F₃N₂
• Molecular Weight: 148.09
• Mol File: 3534-50-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 176.4°C at 760 mmHg
• Flash Point: 60.5°C
• Appearance: /
• Density: 1.517g/cm³
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3,5,6-TRIFLUORO-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,6-TRIFLUORO-PYRIDIN-2-YLAMINE(3534-50-7)
• EPA Substance Registry System: 3,5,6-TRIFLUORO-PYRIDIN-2-YLAMINE(3534-50-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 3534-50-7(Hazardous Substances Data)

Usage

General Description

3,5,6-Trifluoro-pyridin-2-ylamine is a chemical compound categorized under the group of aromatic amines and derivatives. This organofluorine compound features a pyridine heterocyclic ring, with nitrogen as a heteroatom and three fluorine atoms at positions 3, 5, and 6, respectively. It is primarily recognized as an intermediate used in the synthesis of various pharmaceuticals and agricultural chemicals. Despite its prevalence in chemistry and industry, there is relatively limited available data regarding the compound's physical and environmental properties or potential human health effects.

InChI:InChI=1/C5H3F3N2/c6-2-1-3(7)5(9)10-4(2)8/h1H,(H2,9,10)

Upstream product

• 3511-90-8 4-bromo-2,3,5,6-tetrafluoropyridine 
• 12775-96-1 copper 
• 3512-12-7 2-amino-4-bromo-trifluoropyridine 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 851179-05-0 3,5,6-trifluoro-2-hydrazinopyridine 

Relevant articles and documents

(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES

Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

N-Halogeno-compounds. Part 7. Synthesis and Iodine-catalysed Rearrangement to 6-Chloroimino-1-azacyclohexadienes of 4-Substituted 2-(Dichloroamino)-3,5,6-trifluoropyridines

Electrophilic chlorination of the fluorinated 2-aminopyridines 4-X*C5F3N*NH2-2 with t-butyl hypochlorite gave the 2-(dichloroamino)-compounds 4-X*C5F3N*NCl2-2; these isomerized to mixtures of the corresponding 3-chloro-6-chloroimino-1-azacyclohexa-1,4- (predominantly) and 5-chloro-6-chloroimino-1-azacyclohexa-1,3-dienes when treated with iodine. 'Spontaneous' formation of 3-chloro-6-chloroimino-2,3,5-trifluoro-4-methyl-1-azacyclohexa-1,4-diene occurred following chlorination (ButOCl) of 2-amino-3,5,6-trifluoro-4-methylpyridine. 3-Chloro-6-chloroimino- 3,5-difluoro-4-X-2-oxo-1-azacyclohex-4-enes (X = H, Me, or Cl) were obtained by displacement of fluorine from the corresponding 3-chloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,4-dienes with water; hydrolysis of 4,5-dichloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,3-diene provided 4,5-dichloro-6-chloroimino-3,5-difluoro-2-oxo-1-azacyclohex-3-ene.Pyrolysis of the 2-(dichloroamino)pyridines 4-X*C5F3N*NCl2-2 gave the azo-compounds 2,2'-2.The 19F n.m.r. spectra of the chloroimino-1-azacyclohexadienes have been analysed.