3534-50-7

Usage

Uses

Used in Pharmaceutical Industry:
3,5,6-Trifluoro-pyridin-2-ylamine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs with improved efficacy and selectivity.
Used in Agricultural Chemical Industry:
3,5,6-Trifluoro-pyridin-2-ylamine is also utilized as an intermediate in the production of agricultural chemicals. Its incorporation into these compounds can enhance their performance, such as increasing their stability, bioavailability, or target specificity.

InChI:InChI=1/C5H3F3N2/c6-2-1-3(7)5(9)10-4(2)8/h1H,(H2,9,10)

Upstream product

• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 12775-96-1 copper 
• 3512-12-7 2-amino-4-bromo-trifluoropyridine 
• 3511-90-8 4-bromo-2,3,5,6-tetrafluoropyridine 
• 851179-05-0 3,5,6-trifluoro-2-hydrazinopyridine 

Relevant academic research and scientific papers

(AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES

Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

Pyridonecarboxylic acid derivatives or their salts and antibacterial agent comprising the same as the active ingredient

A pyridonecarboxylic acid derivative represented by the following general formula (1): STR1 [wherein R1 represents hydrogen atom or a carboxyl protective group; R2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R3 represents hydrogen atom or a halogen atom; R4 represents hydrogen atom or a halogen atom; R5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH= or --CR7 = (wherein R7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR8 = (wherein R8 represents hydrogen atom, a halogen atom, or a lower alkyl group)] or its salt, as well as an antibacterial agent containing such compound are provided.

N-Halogeno-compounds. Part 7. Synthesis and Iodine-catalysed Rearrangement to 6-Chloroimino-1-azacyclohexadienes of 4-Substituted 2-(Dichloroamino)-3,5,6-trifluoropyridines

Electrophilic chlorination of the fluorinated 2-aminopyridines 4-X*C5F3N*NH2-2 with t-butyl hypochlorite gave the 2-(dichloroamino)-compounds 4-X*C5F3N*NCl2-2; these isomerized to mixtures of the corresponding 3-chloro-6-chloroimino-1-azacyclohexa-1,4- (predominantly) and 5-chloro-6-chloroimino-1-azacyclohexa-1,3-dienes when treated with iodine. 'Spontaneous' formation of 3-chloro-6-chloroimino-2,3,5-trifluoro-4-methyl-1-azacyclohexa-1,4-diene occurred following chlorination (ButOCl) of 2-amino-3,5,6-trifluoro-4-methylpyridine. 3-Chloro-6-chloroimino- 3,5-difluoro-4-X-2-oxo-1-azacyclohex-4-enes (X = H, Me, or Cl) were obtained by displacement of fluorine from the corresponding 3-chloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,4-dienes with water; hydrolysis of 4,5-dichloro-6-chloroimino-2,3,5-trifluoro-1-azacyclohexa-1,3-diene provided 4,5-dichloro-6-chloroimino-3,5-difluoro-2-oxo-1-azacyclohex-3-ene.Pyrolysis of the 2-(dichloroamino)pyridines 4-X*C5F3N*NCl2-2 gave the azo-compounds 2,2'-2.The 19F n.m.r. spectra of the chloroimino-1-azacyclohexadienes have been analysed.