35353-32-3Relevant academic research and scientific papers
Process for the preparation of penam derivatives
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, (2008/06/13)
A process for the preparation of a penam derivative of formula (I): STR1 wherein RA is hydrogen or a group of formula (Ia): STR2 wherein X is --CO2 R1, or SO3 R1 ; R is C1-6 alkyl, aryl, or heterocyclyl; R1 is hydrogen, or a pharmaceutically acceptable salt-forming ion or ester-forming radical, and R2 represents hydrogen or a pharmaceutically acceptable salt-forming ion or in vivo hydrolyzable ester-forming radical; which process comprises reacting a compound of formula (II): STR3 wherein RB is hydrogen, a removable amino blocking group, or a group of formula (IIa): STR4 wherein Y is --CO2 Rx or --SO3 Rx ; R is as defined with respect to formula (I) above; Rx represents an ester-forming radical, RY represents hydrogen, a salt-forming radical or a carboxyl-blocking group, and R3 represents an alkyl, benzyl, or aryl group; with methanol in the presence of copper ions; and thereafter if necessary carrying out one or more of the following steps: (i) removal of any blocking group; (ii) converting the product to a pharmaceutically acceptable salt or ester thereof.
Penicillins
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, (2008/06/13)
A class of penicillins with antibacterial activity having formula (I): STR1 wherein R2 is hydrogen or a pharmaceutically acceptable salting ion or in vivo hydrolyzable ester radical and R1 is hydrogen, a pharmaceutically acceptable salting ion or a pharmaceutically acceptable ester forming radical.
