35368-77-5

Basic information

• Product Name: 2-(2-naphthyloxy)acetamide
• Synonyms: 2-(2-naphthyloxy)acetamide;(2-Naphthalenyloxy)acetamide;1-(2-Amino-2-oxoethoxy)naphthalene;2-(2-naphthyloxy)ethanamide, 98i%
• CAS NO: 35368-77-5
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22124
• EINECS: 252-531-4
• Mol File: 35368-77-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 443.7°Cat760mmHg
• Flash Point: 255.2°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 4.53E-08mmHg at 25°C
• Refractive Index: 1.634
• PKA: 15.33±0.40(Predicted)
• CAS DataBase Reference: 2-(2-naphthyloxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-naphthyloxy)acetamide(35368-77-5)
• EPA Substance Registry System: 2-(2-naphthyloxy)acetamide(35368-77-5)

Safety Data

• Hazardous Substances Data: 35368-77-5(Hazardous Substances Data)

Usage

Physical form

White, crystalline solid

Common use

Pharmaceutical intermediate

Known for

Anti-inflammatory and analgesic properties

Usage

Synthesis of various drugs and medication

Biological and pharmacological activities

Wide range

Research studies

Several for potential therapeutic uses

Precautions

Can cause irritation to skin, eyes, and respiratory system. Should be handled by trained professionals in a laboratory setting.

InChI:InChI=1/C12H11NO2/c13-12(14)8-15-11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8H2,(H2,13,14)

Upstream product

• 135-19-3 β-naphthol 
• 79-07-2 Chloroacetamide 
• 6036-14-2 ethyl (naphthalen-2-yloxy)acetate 
• 120-23-0 (2-naphthoyl)oxyacetic acid 

Relevant articles and documents

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.