35369-28-9

Upstream product

• 56715-75-4 ethyl(3-cyano-2-methoxy)cinnamate 
• 140-29-4 phenylacetonitrile 
• 56715-75-4 3-cyano-2-methoxy-3-phenyl-acrylic acid ethyl ester 

Downstream Products

• 127948-65-6 1-(2-Amino-5-nitro-phenyl)-3-methoxy-4-phenyl-pyrrole-2,5-dione 
• 127948-77-0 (E)-3-(5-Chloro-1H-benzoimidazol-2-yl)-3-methoxy-2-phenyl-acrylic acid 
• 127948-84-9 (E)-3-(1H-Benzoimidazol-2-yl)-3-methoxy-2-phenyl-acrylic acid methyl ester 
• 127948-78-1 (E)-3-Methoxy-3-(5-methyl-1H-benzoimidazol-2-yl)-2-phenyl-acrylic acid 
• 127948-69-0 6-Chloro-3-methoxy-2-phenyl-benzo[d]pyrrolo[1,2-a]imidazol-1-one 
• 127948-70-3 3-Methoxy-6-methyl-2-phenyl-benzo[d]pyrrolo[1,2-a]imidazol-1-one 
• 127948-76-9 β-(2-benzimidazolyl)-β-methoxy-α-phenylacrylic acid 
• 22628-24-6 (E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one 
• 137531-84-1 (Z)-O-methylvulpinic acid 
• 137550-40-4 (E)-5-indoline-2-ylmethylene-4-methyloxy-3-phenylfuran-2(5H)-one 
• 137531-77-2 (Z)-5-indoline-2-ylmethylene-4-methyloxy-3-phenylfuran-2(5H)-one 
• 137531-79-4 (E)-4-methoxy-3-phenyl-5-(4-quinolyl)methylenefuran-2(5H)-one 
• 137531-78-3 (Z)-4-methoxy-3-phenyl-5-(4-quinolyl)methylenefuran-2(5H)-one 
• 137531-81-8 (E)-4-methoxy-3-phenyl-5-(2-thenylidene)furan-2(5H)-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 3-aryl-4-methoxy N-alkyl maleimides

In the present investigation, a series of 3-aryl-4-methoxy N-alkyl maleimide 5a-l have been synthesized and screened for their antimicrobial activity against one Gram positive bacteria (S. aureus), one Gram negative bacteria (E. coli) and fungal strains (C. albicans, C. tropicalis, A. Niger and A. clavatus). The structures of the compounds have been substantiated by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides have been determined by broth microdilution method. Of the newly synthesized maleimides, compounds 5c, 5f, 5h, 5i, 5k and 5l registered significant activity against the tested microorganisms.

Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers

The present invention relates to anti-tumor-conjugation agent-protein compounds of the general formula I: STR1 wherein, R1 and R2 are each independently selected from hydrogen atom, C1-4 alkyl, C1-4 alkoxy, C1-6 carboxyalkyl, phenyl, or phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, or nitro, with the proviso that R1 and R2 cannot be simultaneously a hydrogen, and when one of R1 or R2 is a hydrogen, the other one cannot be --CH2 COOH; A is the residue of an anti-tumor agent containing at least one amino group available to form an amide bound; and B is a free ε-lysine containing residue selected from a peptide or a protein.

Regioselectivity control in metal hydride reductions of substituted maleic anhydrides

A systematic study of reductions of unsymmetrically substituted maleic anhydrides by a variety of metal hydride reagents indicates that the high regioselectivity observed in these reactions is controlled chiefly by electronic factors.