353757-96-7

Upstream product

• 112226-61-6 halofenozide 
• 352320-85-5 benzyl chloro[(chlorocarbonyl)oxy]acetate 
• 52709-42-9 benzylglyoxylate 

Downstream Products

• 352322-05-5 2-(benzoyloxy)-1-[(2,2-dimethylpropanoyl)oxy]-2-oxoethyl 2-benzoyl-2-tert-butyl-1-(4-chlorobenzoyl)hydrazinecarboxylate 
• 352322-18-0 2,2-dimethyl-propionic acid [N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinocarbonyloxy]-carboxy-methyl ester 
• 352321-51-8 [N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinocarbonyloxy]-iodo-acetic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and application of novel glyoxylate-derived chloroformates

A convenient process for the synthesis of glyoxylate-derived chloroformates has been developed. The approach involves the reaction of glyoxylate esters with triphosgene and pyridine in various solvent systems. These novel glyoxylate-derived chloroformates are multifunctional, possessing a chloroformate, ester, and haloalkyl moiety. Further elaboration via a thiocarbonate route afforded highly functionalized carboxylic acid-derived alkoxycarbonyl-chlorocarbonyloxy-methyl esters. Application of a benzyl glyoxylate-derived chloroformate to halofenozide was also accomplished, affording halofenozide-N-carbonyloxy-chloro/iodoacetic acid benzyl ester derivatives, which-were further derivatized to carboxylic acid-derived (halofenozide-N-carbonyloxy)-benzyloxycarbonyl-methyl esters. The trifunctional nature of the glyoxylate moiety was demonstrated through conversion of the benzyloxycarbonyl moiety of a carboxylic acid-derived (halofenozide-N-carbonyloxy)-benzyloxycarbonyl-methyl ester to its respective diethylamide.