353779-31-4

Usage

InChI:InChI=1/C14H16N2O/c1-17-14-8-3-2-6-12(14)10-15-11-13-7-4-5-9-16-13/h2-9,15H,10-11H2,1H3

Upstream product

• 6850-57-3 2-methoxybenzylamine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 135-02-4 ortho-anisaldehyde 
• 7035-02-1 o-Methoxybenzyl chloride 

Downstream Products

• 1258447-83-4 6-bromo-N-(2-methoxybenzyl)-N-(pyridin-2-ylmethyl)hexan-1-amine 
• 1258447-85-6 N-(2-methoxybenzyl)-6-(4-phenylpiperidin-1-yl)-N-(pyridin-2-ylmethyl)hexan-1-amine 
• 1258447-87-8 6-(4-benzylpiperidin-1-yl)-N-(2-methoxybenzyl)-N-(pyridin-2-ylmethyl)hexan-1-amine 
• 1258447-89-0 6-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(2-methoxybenzyl)-N-(pyridin-2-ylmethyl)hexan-1-amine 
• 1258447-99-2 N-(2-tert-butoxybenzyl)-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(pyridin-2-ylmethyl)hexan-1-amine 
• 1258447-97-0 6-bromo-N-(2-tert-butoxybenzyl)-N-(pyridin-2-ylmethyl)hexan-1-amine 

Relevant academic research and scientific papers

Re(I) carbonyl complexes containing pyridyl-imine and amine ligands: Synthesis, characterization and their catalytic olefin epoxidation activities

Re(I) carbonyl complexes containing pyridyl-imine or amine ligands have been synthesized and crystallographically characterized. Their catalytic activity for the cis-cyclooctene epoxidation with tert-butyl hydroperoxide (TBHP) as oxidant and the oxidation of these Re(I) complexes by TBHP have been investigated.

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage

Ascorbate is an important biological reductant and enzyme cofactor. Although direct detection through ascorbate-mediated reduction is possible, this approach suffers from poor selectivity due to the wide range of cellular reducing agents. To overcome this limitation, we leverage reduction potential of ascorbate to mediate a copper-mediated oxidative bond cleavage of ether-caged fluorophores. The copper(II) complexes supported by a {bis(2-pyridylmethyl)}benzylamine or a {bis(2-pyridylmethyl)}(2-methoxybenzyl)amine ligand were identified as an ascorbate responsive unit and their reaction with ascorbate yields a copper-based oxidant that enables rapid benzylic oxidation and the release of an ether-caged dye (coumarin or fluorescein). The copper-mediated bond cleavage is specific to ascorbate and the trigger can be readily derivatized for tuning photophysical properties of the probes. The probes were successfully applied for the fluorometric detection of ascorbate in commercial food samples, human plasma, and serum, and within live cells by using confocal microscopy and flow cytometry.

Molecular probes for ascorbate detection and methods of use

Described are metal complexes for the selective detection of ascorbic acid or ascorbate. The metal complexes act as molecular sensors, and are useful in detecting ascorbate in live biological samples, commercial samples, or both. The selective ascorbate sensing involves an ascorbate-selective bond cleavage reaction. The bond cleavage is not limited to the construction of molecular sensors, but also includes other stimuli-responsive materials, i.e., materials that adopt a physical state, such as gel formation, upon ascorbate-selective bond cleavage of the metal complexes.

COMPOSITIONS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS

The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.