35388-37-5

Basic information

• Product Name: Butanoic acid, 2-[[4-(dimethylamino)phenyl]methylene]-3-oxo-, ethyl ester
• CAS NO: 35388-37-5
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.321
• Mol File: 35388-37-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[[4-(dimethylamino)phenyl]methylene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[[4-(dimethylamino)phenyl]methylene]-3-oxo-, ethyl ester(35388-37-5)
• EPA Substance Registry System: Butanoic acid, 2-[[4-(dimethylamino)phenyl]methylene]-3-oxo-, ethyl ester(35388-37-5)

Safety Data

• Hazardous Substances Data: 35388-37-5(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 78942-33-3 5-Cyano-4-(4-dimethylamino-phenyl)-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 1609547-36-5 ethyl 4-[4-(dimethylamino)phenyl]-2-methyl-4,5-dihydrofuran-3-carboxylate 
• 1449242-54-9 ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-ylamino)-1,4-dihydropyrimidine-5-carboxylate 
• 1449242-49-2 ethyl 4-(4-dimethylaminophenyl)-2-(6-fluoro-4-methylquinazolin-2-ylamino)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 21835-71-2 4-(4-dimethylamino-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 1119750-31-0 2-acetyl-2-ethoxycarbonyl-1-[4-(4-nitrophenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-25-2 2-acetyl-2-ethoxycarbonyl-1-[4-(4-hydroxyphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-40-1 2-acetyl-2-ethoxycarbonyl-1-[4-(4-methylphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-16-1 2-acetyl-2-ethoxycarbonyl-1-[4-(3-methylphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-28-5 2-acetyl-2-ethoxycarbonyl-1-[4-(3-nitrophenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-23-0 2-acetyl-2-ethoxycarbonyl-1-[4-(4-carboxyphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-14-9 2-acetyl-2-ethoxycarbonyl-1-[4-(4-chlorophenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-37-6 2-acetyl-2-ethoxycarbonyl-1-[4-(2-methoxyphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 
• 1119750-20-7 2-acetyl-2-ethoxycarbonyl-1-[4-(3-carboxyphenylazo)phenyl]-3-(4-dimethylaminophenyl)aziridine 

Relevant articles and documents

Design and synthesis of 4-alkyl-2-amino(acetamino)-6-aryl-1,3-thiazine derivatives as influenza neuraminidase inhibitors

With a convenient and economical method, two series of 1,3-thiazine derivatives 1 and 2 were synthesized, and their neuraminidase (NA) inhibitory activities were evaluated. The pharmacological results showed that most of the compounds have potent NA inhibitory activity. Especially, 1g exhibited the best activity against influenza virus A (H1N1) NA (IC50 = 29.06 μg/mL), and its crystal structure was determined by single-crystal X-ray diffraction. The preliminary biological assay indicated that 1,3-thiazine could be used as a core structure to design novel influenza NA inhibitors. Two series of novel 1,3-thiazine analogs were synthesized and their neuraminidase (NA) inhibitory activities were evaluated. Most of the compounds have potent NA inhibitory activity. Compound 1g exhibited the best activity against influenza virus A (H1N1) NA with an IC50 of 29.06 μg/mL, and its crystal structure was determined by single-crystal X-ray diffraction.

Synthesis and QSAR modeling of 2-acetyl-2-ethoxycarbonyl-1-[4(4′-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines as potential antibacterial agents

The present communication deals with the synthesis of a series of 2-acetyl-2-ethoxycarbonyl-1-[4(4′-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the