35451-46-8

Usage

Uses

Used in Organic Synthesis:
4-Pyridinecarboximidic acid, methyl ester is used as a building block for the creation of various organic compounds. Its versatile structure allows it to be a key component in the synthesis of a wide range of molecules.
Used in Chemical Reactions:
As a reagent, 4-Pyridinecarboximidic acid, methyl ester is utilized in different chemical reactions to facilitate the formation of desired products or to drive specific chemical processes.
Used in Pharmaceutical Synthesis:
4-Pyridinecarboximidic acid, methyl ester serves as a starting material for the synthesis of various pharmaceuticals. Its presence in the initial stages of production is crucial for developing new drugs and medicines.
Used in Agrochemical Production:
4-Pyridinecarboximidic acid, methyl ester is also used as a starting material in the synthesis of agrochemicals, playing a significant role in the development of products that protect and enhance crop yields and quality.

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 67-56-1 methanol 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 6345-27-3 4-amidinopyridine hydrochloride 
• 898561-44-9 C₁₃H₁₄N₄O₃S 
• 898561-43-8 C₁₃H₁₄N₄O₂S 
• 898561-42-7 C₁₂H₁₂N₄O₂S 
• 104326-63-8 methyl N-(o-trifluoromethyl-benzoyl)-4-pyridylcarboximidate 
• 2295-47-8 2-(pyridin-4-yl)benzoxazole 
• 308362-25-6 2,2'-bis(4-pyridyl)3H,3'-H 5,5-bibenzimidazole 
• 1431319-92-4 N'-[(2-chlorophenyl)sulfonyl]-4-pyridinecarboximidamide 
• 1082936-94-4 C₂₃H₂₀ClN₅O₃S 
• 110193-47-0 2-[3-(2-Pyridin-4-yl-4,5-dihydro-oxazol-5-yl)-phenoxymethyl]-quinoline 
• 182416-47-3 1-benzyl-4-(4-methylpyrimidin-2-yl)-1,2,3,6-tetrahydropyridine 
• 182416-07-5 1-benzyl-4-(2-pyrimidinyl)-1,2,3,6-tetrahydropyridine 

Relevant academic research and scientific papers

Alkali α-MnO2/Na: XMnO2 collaboratively catalyzed ammoxidation-Pinner tandem reaction of aldehydes

The tandem reaction is a growing field to yield important advances toward green and sustainable chemistry. Herein, we report a bifunctional manganese oxide catalyst with an interface binding redox phase (α-MnO2) and a basic phase (NaxMnO2). The molar ratio of NaOH/Mn plays a great role in the formation of α-MnO2/NaxMnO2. The sodium cation is essential for the formation of a basic NaxMnO2 phase while the potassium cation promotes the formation of a redox-active α-MnO2 phase. The interface structure of α-MnO2/NaxMnO2 geometrically favors the ammoxidation-Pinner tandem reaction to synthesize imidates in a 58-96% yield from aldehydes. Thus a phase collaborative effect is observed. In the ammoxidation process, the redox cycle of MnIV/MnIII is involved and the lattice oxygen in the α-MnO2 phase acts as an active oxygen species. The O-H in methanol is activated and dissociated on the basic sites of NaxMnO2 to the adsorbed methoxyl species to facilitate the Pinner synthesis. This approach bypasses the conventional synthesis of imidates, which suffer from harsh reaction conditions and the requirement for multiple steps.

Synthesis of amidines and benzoxazoles from activated nitriles with Ni(0) catalysts

Amidines and 2-substituted benzoxazoles were synthesized from N-heterocyclic nitriles under mild conditions (50 °C, 48 h, two steps) in an atom-economical process that involves addition of methanol, the solvent, to a nitrile moiety to yield a methyl imidate and the subsequent extrusion of solvent in the presence of amines to afford the title compounds. Methyl imidate formation was achieved by developing a new catalytic pathway using [(dippe)Ni(H)]2 (dippe = 1,2-bis(diisopropylphosphino)ethane), [Ni(cod)2]/dppe, or [Ni(cod)2]/P(OPh)3 (cod = 1,5-cyclooctadiene, dppe = 1,2-bis(diphenylphosphino)ethane, P(OPh)3 = triphenyl phosphite) as the catalyst precursor. Regarding the ligands, for a given substrate, namely 4-cyanopyridine, the best performance for the Ni(0)-catalyzed system was found for the σ-donor bidentate dippe, whereas the monodentate π acceptor P(OPh)3 was less efficient. In relation to the substrates, for a given Ni-dippe system, steric hindrance and, more importantly, substrate electron-withdrawing character control imidate formation and thus the yield of amidines and benzoxazoles.

NaY zeolite: A useful catalyst for nitrile hydrolysis

The NaY zeolite catalysed hydrolysis of nitriles to primary amides is reported. It is found that aryl nitriles with strong electron-withdrawing substituents and cyanopyridines are readily hydrolysed in the water suspension, while aliphatic nitriles do not react.