354554-60-2

Upstream product

• 100-52-7 benzaldehyde 
• 55023-32-0 4,6-dimethylthieno[2,3-b]pyridine-3(2H)-one 
• 109-77-3 malononitrile 
• 2700-22-3 Benzylidenemalononitrile 

Relevant academic research and scientific papers

Synthesis of substituted 2-amino-3-cyano-7,9-dimethyl-4H-pyrano[2′, 3′:4,5]thieno[2,3-b]pyridines

4,6-Dimethyl-2H-thieno[2,3-b]pyridin-3-one reacts with 2-aryl-1,1- dicyanoethylenes or an aromatic aldehyde/ketone (cyclohexanone and piperidone derivatives) and malononitrile to give substituted 2-amino-3-cyano-7,9-dimethyl- 4H-pyrano[2′,3′:4,5]thieno[2,

Synthesis of Pyridothienopyridines and Arylazothienopyridines

Treatment of aminothienopyridine 3 with arylidenemalononitrile affords pyridothienopyridine 4. Condensation of 3 with ethyl ethoxymethylene-cyanoacetate affords compound 5, which may be cyclised in diphenyl ether into pyridothienopyridine 6. Thiourea derivative 7 is cyclised using Br2/AcOH, and ethyl chloroacetate to afford thiazolothienopyridine 8 and thiazolidinylthienopyridine 9 respectively. Compound 15 is condensed with aromatic aldehydes to give the corresponding arylidenethienopyridines 16a-d. The latter compounds undergo Michael addition with malononitrile to produce pyranothienopyridines 17a-d. Compound 15 was coupled with aromatic diazonium chloride to give the corresponding 2-arylazothienopyridine derivatives 20, but when treated with nitrous acids it dimerised to compound 19.

Synthesis of pyridothienopyridines and arylazothienopyridines

Treatment of aminothienopyridine 3 with arylidenemalononitrile afford pyridothienopyridine 4. Also condensation of 3 with ethyl ethoxymethylene- cyanoacetae afford compound 5, which was cyclized in diphenyl ether into pyridothienopyridine 6. Thiourea deri