35461-98-4

Usage

Uses

Used in Organic Synthesis:
4-(2-Furyl)benzoic acid is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the creation of new molecules.
Used in Pharmaceutical Manufacturing:
4-(2-Furyl)benzoic acid is used as a building block in the production of specific pharmaceutical compounds. Its presence in the molecular structure can contribute to the development of drugs with desired therapeutic properties, such as improved efficacy or reduced side effects.
Used in Chemical Research:
4-(2-Furyl)benzoic acid is used as a research tool in the study of chemical reactions and mechanisms. Its reactivity and structural features make it an interesting subject for scientists to explore and understand the underlying principles of chemical interactions.

InChI:InChI=1/C11H8O3/c12-11(13)9-5-3-8(4-6-9)10-2-1-7-14-10/h1-7H,(H,12,13)

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 81745-86-0 2-furylzinc chloride 
• 118486-94-5 2-(tributylstannyl)furan 
• 586-76-5 4-Bromobenzoic acid 
• 13331-23-2 fur-2-ylboronic acid 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 497-19-8 sodium carbonate 
• 150-13-0 4-amino-benzoic acid 
• 110-00-9 furan 
• 456-25-7 p-carboxyphenyl diazonium tetrafluoroborate 

Relevant academic research and scientific papers

Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing

Optimization of benzamide PPARδ modulator 1 led to (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-4-methylhex-4-enoic acid (18), a potent selective PPARδ modulator with significantly improved exposure in multiple species following oral administration.

Compound with PPAR delta agonistic activity, pharmaceutical composition and medical application

The invention discloses a compound with PPAR delta agonistic activity, a pharmaceutical composition and medical application, wherein the structure of the compound is shown as a formula I in the specification. The compound shown in the formula I is a novel

Effective bimetallic composite catalysts for the synthesis of arylated furans and thiophenes in aqueous media

[Figure not available: see fulltext.] N-(4,6-Dimethylpyrimidin-2-yl)-5-phenylisoxazole-3-carboxamide was used as a ligand for obtaining bimetallic boron-containing heterogeneous catalysts Pd–Ni(Co)–B–L (Ni(Co):Pd = 9:1). The obtained composites were highl

Facile C–H arylation using catalytically active terminal sulfurs of 2 dimensional molybdenum disulfide

The first methodology of C–H arylation of heteroarene via 2D transition metal dichalcogenides that have catalytically active edge functional groups was described. The terminal sulfur groups could effectively catalyze a formation of an azo-linked intermediate with aryl diazonium salts, leading to produce heteroarenes with good yields. This novel methodology using bulk 2D transition metal dichalcogenides that have catalytically active edge functional groups can apply for various reactions to achieve C–C bond formation in the fields of heterogeneous catalysis that is easily separable, highly reusable, and inexpensive method.

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).

PPAR AGONISTS AND METHODS OF USE THEREOF

Provided herein are deuterated compounds and compositions useful in increasing PPAR5 activity. The compounds and compositions provided herein are useful for the treatment of PPAR5 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

High-turnover aminopyridine-based Pd-catalysts for Suzuki-Miyaura reaction in aqueous media

A high-turnover catalytic system based on commercially available aminopyridines (L) and PdCl2 has been developed for Suzuki-Miyaura reaction in aqueous media. Reactions of arylboronic acids with a wide range of aryl iodides, bromides and chlorides proceeded in the presence of these catalysts for a short time in aqueous media to afford the cross-coupling products in high yields. Furthermore, this protocol allows tolerating a wide range of functional groups.

Ascorbic acid as an initiator for the direct C-H arylation of (hetero)arenes with anilines nitrosated in situ

Ascorbic acid (vitaminC) has been used as a radical initiator in a metal-free direct C-H arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitaminC to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation. Copyright

An effective activation of palladium phosphine complexes in aqueous phase reactions of hetero-aromatic boronic acids with aryl halides

We have developed a simple and effective method for the activation of palladium phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h-1) by selecting an aqueous reaction medium instead of organic solvents. This method wa

5-(Naphth-1-yl)- and 5-[(1,1'-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes: Synthesis, complexes with palladium, and application in catalysis

1-(Naphth-1-yl)- and 1-[(1,1'-biphenyl)-4-yl-3,4,4-trichloro-3-buten-1-ones were synthesized by acylation of naphthalene and biphenyl with 3,4,4-trichloro-3-butenoyl chloride. Further reaction with hydroxylamine led to 5-(naphth-1-yl)- and 5-[(1,1'-biphen