3548-09-2

Basic information

• Product Name: 9-AMINO-6-CHLORO-2-METHOXYACRIDINE
• Synonyms: 5-amino-2-chloro-7-methoxyacridine;6-chloro-2-methoxy-9-acridinamin;6-chloro-2-methoxy-9-acridinamine;9-amino-3-chloro-7-methoxy-acridin;9-amino-6-chloro-2-methoxy-acridin;9-AMINO-6-CHLORO-2-METHOXYACRIDINE;ACMA;2-Methoxy-6-chloro-9-aminoacridine
• CAS NO: 3548-09-2
• Molecular Formula: C₁₄H₁₁ClN₂O
• Molecular Weight: 258.7
• Product Categories: API intermediates;Fluorescent;Acridine
• Mol File: 3548-09-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: >250°C
• Boiling Point: 475.1 °C at 760 mmHg
• Flash Point: 241.2 °C
• Appearance: Yellow/Solid
• Density: 1.367 g/cm³
• Vapor Pressure: 3.4E-09mmHg at 25°C
• Refractive Index: 1.734
• Storage Temp.: −20°C
• Solubility: Solubility Insoluble in water; soluble in N, N-dimethylformamide
• PKA: 8.6(at 25℃)
• CAS DataBase Reference: 9-AMINO-6-CHLORO-2-METHOXYACRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 9-AMINO-6-CHLORO-2-METHOXYACRIDINE(3548-09-2)
• EPA Substance Registry System: 9-AMINO-6-CHLORO-2-METHOXYACRIDINE(3548-09-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-40
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: AR7330000
• Hazardous Substances Data: 3548-09-2(Hazardous Substances Data)

Usage

General Description

9-Amino-6-chloro-2-methoxyacridine is a chemical compound with the molecular formula C15H11ClN2O. It is an acridine derivative that is used in various applications such as in the synthesis of pharmaceuticals and dyes. 9-Amino-6-chloro-2-methoxyacridine is known for its potential antimicrobial and antitumor activities, and has been studied for its potential use in cancer treatment. It is a yellow to green solid that is sparingly soluble in water but soluble in organic solvents. 9-Amino-6-chloro-2-methoxyacridine is also used as a staining agent in microscopy and is a valuable tool in biological and medical research.

InChI:InChI=1/C14H11ClN2O/c1-18-9-3-5-12-11(7-9)14(16)10-4-2-8(15)6-13(10)17-12/h2-7H,1H3,(H2,16,17)

Upstream product

• 86-38-4 6,9-dichloro-2-methoxyacridine 
• 210584-71-7 6-chloro-2,9-dimethoxyacridine 
• 98570-61-7 (6-chloro-2-methoxy-acridin-9-yl)-hydrazine 
• 69-05-6 quinacrine dihydrochloride 

Downstream Products

• 83-89-6 quinacrine 

Relevant articles and documents

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.

On the photoinduced conversion of Atebrin

-