354806-68-1Relevant academic research and scientific papers
Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold
Tietz, Ole,Sharma, Sai Kiran,Kaur, Jatinder,Way, Jenilee,Marshall, Alison,Wuest, Melinda,Wuest, Frank
, p. 8052 - 8064 (2013/12/04)
Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental da
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
Swarbrick, Martin E.,Beswick, Paul J.,Gleave, Robert J.,Green, Richard H.,Bingham, Sharon,Bountra, Chas,Carter, Malcolm C.,Chambers, Laura J.,Chessell, Iain P.,Clayton, Nick M.,Collins, Sue D.,Corfield, John A.,Hartley, C. David,Kleanthous, Savvas,Lambeth, Paul F.,Lucas, Fiona S.,Mathews, Neil,Naylor, Alan,Page, Lee W.,Payne, Jeremy J.,Pegg, Neil A.,Price, Helen S.,Skidmore, John,Stevens, Alexander J.,Stocker, Richard,Stratton, Sharon C.,Stuart, Alastair J.,Wiseman, Joanne O.
scheme or table, p. 4504 - 4508 (2010/04/05)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have been dis
Pyrmidine derivatives as selective inhibitors of cox-2
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, (2008/06/13)
The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl, R3 is C1-6alkyl or NH
