342651-55-2Relevant academic research and scientific papers
Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold
Tietz, Ole,Sharma, Sai Kiran,Kaur, Jatinder,Way, Jenilee,Marshall, Alison,Wuest, Melinda,Wuest, Frank
, p. 8052 - 8064 (2013/12/04)
Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental da
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
Swarbrick, Martin E.,Beswick, Paul J.,Gleave, Robert J.,Green, Richard H.,Bingham, Sharon,Bountra, Chas,Carter, Malcolm C.,Chambers, Laura J.,Chessell, Iain P.,Clayton, Nick M.,Collins, Sue D.,Corfield, John A.,Hartley, C. David,Kleanthous, Savvas,Lambeth, Paul F.,Lucas, Fiona S.,Mathews, Neil,Naylor, Alan,Page, Lee W.,Payne, Jeremy J.,Pegg, Neil A.,Price, Helen S.,Skidmore, John,Stevens, Alexander J.,Stocker, Richard,Stratton, Sharon C.,Stuart, Alastair J.,Wiseman, Joanne O.
scheme or table, p. 4504 - 4508 (2010/04/05)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have been dis
USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS
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, (2008/06/13)
The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.
COMPOSITIONS CONTAINING PYRIMIDINE DERIVATIVES AS INHIBITORS OF COX-2
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Page 19, (2010/02/07)
The invention provides a pharmaceutical composition comprising a compound of formula (I), a potent and selective inhibitor of COX-2, in which the compound is present in solid particles in nanoparticulate form in admixture with one or more pharmaceutically
Pyrimidine derivatives
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Page column 12, (2008/06/13)
The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1and R2are independently selected from H, C1-6alkyl, C2-6alkenyl, C3-6alkynyl, Csub
