354988-08-2

Basic information

• Product Name: (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene
• Synonyms: (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene
• CAS NO: 354988-08-2
• Molecular Weight: 273.375
• Mol File: 354988-08-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene(CAS DataBase Reference)
• NIST Chemistry Reference: (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene(354988-08-2)
• EPA Substance Registry System: (5R)-5-[N-(tert-butoxycarbonyl)amino]-6-phenylhexa-1,2-diene(354988-08-2)

Safety Data

• Hazardous Substances Data: 354988-08-2(Hazardous Substances Data)

Upstream product

• 141403-49-8 (2S)-2-[N-(tert-butoxycarbonyl)amino]-3-phenyl-O-(4-methylphenylsulfonyl)propan-1-ol 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 6165-76-0 propargyl p-toluenesulfonate 
• 154669-56-4 (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-iodo-3-phenylpropane 

Downstream Products

• 252652-90-7 (5R)-6-phenyl-5-[N-(2,4,6-trimethylphenylsulfonyl)amino]hexa-1,2-diene 
• 252652-89-4 (5R)-5-[N-(4-methylphenylsulfonyl)amino]-6-phenylhexa-1,2-diene 

Relevant articles and documents

Stereoselective synthesis of 2-alkenylaziridines and 2-alkenylazetidines by palladium-catalyzed intramolecular amination of α- and β-amino allenes

Whereas palladium-catalyzed reaction of N-arylsulfonyl-α-amino allenes with an aryl iodide (4 equiv) in the presence of potassium carbonate (4 equiv) in DMF at around 70 °C affords the corresponding 3-pyrroline derivatives, the reaction in refluxing 1,4-dioxane under otherwise identical conditions yields exclusively or most predominantly the corresponding 2-alkenylaziridines bearing an aryl group on the double bond. Similarly, N-arylsulfonyl-β-amino allenes can be also cyclized into the corresponding alkenylazetidines bearing a 2,4-cis-configuration under palladium-catalyzed cyclization conditions in DMF.