354988-39-9

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 354988-38-8 (3R,5R)-6-methyl-5-[N-(2,4,6-trimethyl-phenylsulfonyl)amino]-hept-1-yn-3-ol 
• 354988-33-3 (3R,5R)-5-[N-(tert-butoxycarbonyl)amino]-6-methyl-1-trimethylsilylhept-1-yn-3-ol 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 172695-23-7 (R)-3-<(tert-butoxycarbonyl)amino>-4-methylpentanenitrile 
• 124754-81-0 tert-butyl [(1R)-2-methyl-1-(2-oxoethyl)propyl]carbamate 
• 354988-37-7 (3R,5R)-5-[N-(tert-butoxycarbonyl)amino]-6-methylhept-1-yn-3-ol 

Relevant academic research and scientific papers

A highly cis-selective synthesis of 2-ethynylaziridines by intramolecular amination of chiral bromoallenes: Improvement of stereoselectivity based on the computational investigation

The base-mediated intramolecular amination of bromoallenes having an axial chirality is described. The treatment of (4S,aR)-4-alkyl-4-[N-(arylsulfonyl)amino]-1-bromobuta-1,2-dienes with NaH in DMF affords 2,3-cis-2-ethynylaziridines in good to excellent s

Stereoselective synthesis of 2-alkenylaziridines and 2-alkenylazetidines by palladium-catalyzed intramolecular amination of α- and β-amino allenes

Whereas palladium-catalyzed reaction of N-arylsulfonyl-α-amino allenes with an aryl iodide (4 equiv) in the presence of potassium carbonate (4 equiv) in DMF at around 70 °C affords the corresponding 3-pyrroline derivatives, the reaction in refluxing 1,4-dioxane under otherwise identical conditions yields exclusively or most predominantly the corresponding 2-alkenylaziridines bearing an aryl group on the double bond. Similarly, N-arylsulfonyl-β-amino allenes can be also cyclized into the corresponding alkenylazetidines bearing a 2,4-cis-configuration under palladium-catalyzed cyclization conditions in DMF.