35504-94-0

Basic information

• Product Name: 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid
• CAS NO: 35504-94-0
• Molecular Weight: 269.095
• Mol File: 35504-94-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid(35504-94-0)
• EPA Substance Registry System: 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid(35504-94-0)

Safety Data

• Hazardous Substances Data: 35504-94-0(Hazardous Substances Data)

Upstream product

• 32095-89-9 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid methyl ester 
• 711-33-1 4-trifluoromethyl propiophenone 
• 298-12-4 Glyoxilic acid 
• 10026-13-8 phosphorus pentachloride 
• 107413-78-5 5-anilino-5-(4-bromo-phenyl)-4-methyl-5H-furan-2-one 
• 859940-27-5 4-(4-bromo-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid 
• 108-86-1 bromobenzene 

Downstream Products

• 106274-52-6 4-oxo-3-methyl-4-(4-bromo-phenyl)-trans-crotonic acid dimethylamide 
• 101735-35-7 4-oxo-3-methyl-4-(4-bromo-phenyl)-trans-crotonic acid-(N-methyl-anilide) 
• 32095-93-5 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid methyl ester 
• 52241-04-0 (+/-)-4-(4-bromophenyl)-3-methyl-4-oxobutyric acid 
• 35513-28-1 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid 

Relevant articles and documents

Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione

Herein, we report a safe and economical multigram synthesis of 6-fluoromenadione, an intermediate in the synthesis of novel biologically active agents. The key to this six-step sequence process involves the condensation of the readily available starting 4′-fluoropropiophenone and glyoxylic acid, a bromination-elimination sequence from 7-fluoro-3-methyltetral-1-one allowing aromatization of the naphthol intermediate, which is then oxidized into the corresponding 6-fluoromenadione. The multigram process has been demonstrated from 25 g of starting material scale with an improved overall yield of 50% and then applied to five other 7-substituted 3-methyltetralones and their corresponding 6-substituted menadiones.