35513-28-1

Basic information

• Product Name: 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid
• Synonyms: 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid
• CAS NO: 35513-28-1
• Molecular Weight: 269.095
• Mol File: 35513-28-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid(35513-28-1)
• EPA Substance Registry System: 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid(35513-28-1)

Safety Data

• Hazardous Substances Data: 35513-28-1(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 616-02-4 citraconic acid anhydride 
• 35504-94-0 4-(4-bromo-phenyl)-3-methyl-4-oxo-trans-crotonic acid 
• 99983-28-5 5-(4-bromo-phenyl)-5-hydroxy-4-methyl-1,5-dihydro-pyrrol-2-one 
• 7664-93-9 sulfuric acid 
• 7446-70-0 aluminium trichloride 
• 10342-83-3 4'-Bromopropiophenone 
• 298-12-4 Glyoxilic acid 
• 711-33-1 4-trifluoromethyl propiophenone 
• 67-56-1 methanol 

Downstream Products

• 860002-28-4 5-(4-bromo-phenyl)-5-methoxy-4-methyl-5H-furan-2-one 
• 99867-11-5 5-(4-bromo-phenyl)-5-chloro-4-methyl-5H-furan-2-one 
• 52241-04-0 (+/-)-4-(4-bromophenyl)-3-methyl-4-oxobutyric acid 
• 32095-93-5 4-(4-bromo-phenyl)-3-methyl-4-oxo-cis-crotonic acid methyl ester 
• 150424-75-2 4-(4-bromo-phenyl)-3-methyl-4-oxo-butyric acid ethyl ester 
• 150424-74-1 4-(4-bromo-phenyl)-3-methyl-4-oxo-butyric acid methyl ester 

Relevant articles and documents

Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione

Herein, we report a safe and economical multigram synthesis of 6-fluoromenadione, an intermediate in the synthesis of novel biologically active agents. The key to this six-step sequence process involves the condensation of the readily available starting 4′-fluoropropiophenone and glyoxylic acid, a bromination-elimination sequence from 7-fluoro-3-methyltetral-1-one allowing aromatization of the naphthol intermediate, which is then oxidized into the corresponding 6-fluoromenadione. The multigram process has been demonstrated from 25 g of starting material scale with an improved overall yield of 50% and then applied to five other 7-substituted 3-methyltetralones and their corresponding 6-substituted menadiones.

SUBSTITUTED THIO-SUBSTITUTED BENZYL-PROPIONYL-L-PROLINES

This disclosure describes novel substituted ω-aroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.