35510-04-4

Upstream product

• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 335612-69-6 [4-bromo-3-(hydroxymethyl)phenyl]methanol 
• 6939-93-1 4-bromo-isophthalic acid 
• 583-70-0 1-bromo-2,4-dimethylbenzene 

Downstream Products

• 1416159-10-8 (2,4-bis((2,4-bis((2-methoxyethoxy)methoxy)phenoxy)methyl)phenyl)boronic acid 
• 1416159-05-1 (2,4-bis((2,4-dihydroxyphenoxy)methyl)phenyl)boronic acid 
• 1416159-08-4 4,4'-(((4-bromo-1,3-phenylene)bis(methylene))bis(oxy))bis(1,3-bis((2-methoxyethoxy)methoxy)benzene) 
• 1422268-67-4 C₃₄H₃₇BrN₄ 
• 1422268-58-3 C₂₅H₃₃N₅ 
• 1422268-55-0 C₂₇H₃₆N₆ 
• 1422268-77-6 C₃₀H₄₁N₅O₂ 
• 1422268-75-4 C₃₀H₃₉N₅O₂ 
• 1422268-73-2 C₄₂H₅₁N₅O₂ 
• 1422268-69-6 C₃₉H₄₈N₆ 
• 55705-29-8 4,12-Dimethyl<2,2>metacyclophan 

Relevant academic research and scientific papers

A thermally-stable enzyme detection assay that amplifies signal autonomously in water without assistance from biological reagents

This Communication describes a thermally-stable small molecule and a corresponding assay strategy that autonomously amplifies a colorimetric signal when a specific enzyme biomarker is detected. This journal is

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase

Nitric oxide synthases (NOSs) comprise three closely related isoforms that catalyze the oxidation of l-arginine to l-citrulline and the important second messenger nitric oxide (NO). Pharmacological selective inhibition of neuronal NOS (nNOS) has the potential to be therapeutically beneficial in various neurodegenerative diseases. Here, we present a structure-guided, selective nNOS inhibitor design based on the crystal structure of lead compound 1 in nNOS. The best inhibitor, 7, exhibited low nanomolar inhibitory potency and good isoform selectivities (nNOS over eNOS and iNOS are 472-fold and 239-fold, respectively). Consistent with the good selectivity, 7 binds to nNOS and eNOS with different binding modes. The distinctly different binding modes of 7, driven by the critical residue Asp597 in nNOS, offers compelling insight to explain its isozyme selectivity, which should guide future drug design programs.