355116-17-5

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 93-89-0 benzoic acid ethyl ester 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 3623-15-2 phenyl propargyl ketone 
• 1446135-04-1 1-phenyl-2-(1H-tetrazol-5-yl)ethanone oxime 
• 1446135-23-4 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone oxime 
• 1446135-24-5 2-(1-(4-nitrobenzyl)-1H-tetrazol-5-yl)-1-phenylethanone oxime 
• 1446135-30-3 2-(2-(4-nitrobenzyl)-2H-tetrazol-5-yl)-1-phenylethanone oxime 
• 1446135-35-8 2-(1-benzyl-1H-tetrazol-5-yl)-3-phenyl-2H-azirine 
• 1446135-36-9 3-phenyl-2-(1-(4-nitrobenzyl)-1H-tetrazol-5-yl)-2H-azirine 
• 1446135-40-5 3-phenyl-2-(2-(4-nitrobenzyl)-2H-tetrazol-5-yl)-2H-azirine 
• 1446135-47-2 2-(1-(4-nitrobenzyl)-1H-tetrazol-5-yl)-1-phenylethanone O-tosyl oxime 
• 1446135-06-3 2-(1-trityl-1H-tetrazol-5-yl)-1-phenylethanone 
• 1446135-14-3 2-(2-trityl-2H-tetrazol-5-yl)-1-phenylethanone 
• 1446135-17-6 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone 
• 116991-75-4 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone 
• 1446135-09-6 2-(1-(4-nitrobenzyl)-1H-tetrazol-5-yl)-1-phenylethanone 

Relevant academic research and scientific papers

The neber approach to 2-(tetrazol-5-yl)-2 H -azirines

The synthesis of 2-(tetrazol-5-yl)-2H-azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2H-azirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3. It was demonstrated that the alkaloid-mediated Neber reaction allows the asymmetric synthesis of 2-(tetrazol-5-yl)-2H-azirines.

2-ACYLAMINOTHIAZOLE DERIVATIVES

The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A2A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.

The reaction of 2-(tetrazol-5-yl)alkyl ketones and of 2-(tetrazol-5-yl)alkanoic acid derivatives with lead tetraacetate. A novel method of preparation of alk-2-ynyl ketones and alk-2-ynoic acid derivatives

The majority of tetrazolylacetyl derivatives 2 and 7, when treated with lead tetraacetate in dry 1,4-dioxane at room or lower temperature, are oxidized with elimination of molecular nitrogen mainly to the corresponding alkynoyl derivatives 4 and 8, respectively. Vinylidenes (25) have been shown to be the intermediates of the reaction. The reaction does not take place when either the tetrazolyl group is N-substituted or the carbon atom separating the tetrazolyl and the carbonyl groups is disubstituted or these two groups are separated by two carbon atoms as in compound 17. The reaction offers a convenient method for the conversion of 2-cyanoacetyl derivatives into alk-2-ynoyl derivatives via intermediate tetrazolylacetyl derivatives. The 4-methoxyanilide 7o reacts differently, affording the fused heterocyclic compounds 19o and 20o.