35524-41-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structure and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(2-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE serves as a valuable compound for research purposes. Its properties allow scientists to explore its potential in creating novel biologically active molecules, which could lead to the discovery of new treatments for various diseases and conditions.

InChI:InChI=1/C12H11NO/c1-10-5-2-3-7-12(10)13-8-4-6-11(13)9-14/h2-9H,1H3

Upstream product

• 2437-42-5 1-o-tolyl-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 95-53-4 o-toluidine 
• 4497-57-8 2,2,4-trimethyl-3,4-dihydroquinoline-1(2H)-carbaldehyde 
• 2700-30-3 N,N-diisorpopylformamide 
• 607-00-1 diphenylformamide 
• 52008-97-6 N-isopropyl-N-phenylformamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 680995-66-8 C₁₂H₁₃NO 

Relevant academic research and scientific papers

Construction of N-C Axial Chirality through Atroposelective C-H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N-arylindoles is reported. The crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, a wide range of arylindoles and functional alkenes could be well tolerated. Moreover, the practicality and synthetic value of this process were demonstrated by the divers and simple transformations of the products.

Direct and efficient synthesis of pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles with sterically crowded amides

A simple and convenient synthetic method to prepare N-substituted pyrrole-3-carbaldehydes by Vilsmeier-Haack formylation of pyrroles using sterically crowded formamides was developed. The dependence of the formylation regioselectivity on steric features of substrates and reagents is discussed. Georg Thieme Verlag Stuttgart · New York.

Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT 7 receptor ligands

Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.