35524-76-6

Upstream product

• 85937-47-9 N-methyl-N,2-diphenylbutanamide 
• 1188327-74-3 N-(2-chlorophenyl)-N-methyl-2-phenylbutanoic acid amide 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 615-36-1 2-bromoaniline 
• 95-51-2 o-chloroaniline 
• 615-43-0 2-iodophenylamine 
• 36854-57-6 2-Phenylbutyryl chloride 
• 348-54-9 2-Fluoroaniline 
• 349088-21-7 C₁₆H₁₆INO 
• 349537-82-2 C₁₆H₁₆BrNO 
• 349418-67-3 C₁₆H₁₆FNO 
• 1386995-94-3 N-(2-iodophenyl)-N-methyl-2-phenylbutanamide 
• 1386995-93-2 N-(2-fluorophenyl)-N-methyl-2-phenylbutanamide 

Relevant academic research and scientific papers

A benzene-bridged divanadium complex-early transition metal catalyst for alkene alkylarylation with PhI(O2CR)2viadecarboxylation

The synthesis, structure and catalytic activity of a benzene-bridged divanadium complex were comprehensively studied. The reduction of (Nacnac)VCl2(1) (Nacnac = (2,6-iPr2C6H3NCMe)2HC) supported by β-diketiminate with potassium graphite (KC8) by employing benzene as the solvent allows access to the benzene-bridged inverted-sandwich divanadium complex (μ-η6:η6-C6H6)[V(Nacnac)]2(2a), which can catalyze alkene alkylarylation with hypervalent iodine(iii) reagents (HIRs)viadecarboxylation to generate regioselectively diverse indolinones. Furthermore, the mild nature of this reaction was amenable to a wide range of functionalities on alkenes and HIRs. Mechanistic studies revealed a relay sequence of decarboxylative radical alkylation/radical arylation/oxidative re-aromatization.

Iron-catalyzed oxidative arylmethylation of activated alkenes using a peroxide as the methyl source

A novel, simple route for the synthesis of oxindoles is presented via iron-catalyzed oxidative arylmethylation of activated alkenes with peroxides. This work is realized by the use of a peroxide as the methyl source and 1,4-diazabicyclo[2.2.2]octane as the ligand and represents a new access to oxindoles through an alkene oxidative difunctionalization process. Georg Thieme Verlag Stuttgart. New York.

Transition-metal-free synthesis of oxindoles by potassium tert-butoxide-promoted intramolecular α-arylation

Potassium tert-butoxide-mediated intramolecular α-arylations of fluoro- and chloro-substituted anilides provide oxindoles in DMF at 80 °C. In this manner, diversely substituted products have been obtained in moderate to high yields.

Air-stable secondary phosphine oxide as preligand for palladium-catalyzed intramolecular a-arylations with chloroarenes

A palladium catalyst derived from air-stable secondary phosphlne oxide (1-Ad)2P(O)H enabled efficient Intramolecular a-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.

Oxindole synthesis by direct coupling of Csp2-H and C sp3-H centers

(Chemical Equation Presented) An sp2/sp3 get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl Csp2-H and a Csp3-H center (see scheme; DMF = N,N-dimethylformamide).