35530-10-0

Basic information

• Product Name: [(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol] hydrochloride
• Synonyms: [(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol] hydrochloride
• CAS NO: 35530-10-0
• Molecular Weight: 248.666
• Mol File: 35530-10-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol] hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol] hydrochloride(35530-10-0)
• EPA Substance Registry System: [(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol] hydrochloride(35530-10-0)

Safety Data

• Hazardous Substances Data: 35530-10-0(Hazardous Substances Data)

Upstream product

• 103-64-0 bromostyrene 
• 2425-28-7 2-Bromo-1-phenylethanol 
• 77940-37-5 5-bromo-4-phenyl-[1,3]dioxane 
• 100-42-5 styrene 
• 54299-23-9 (+/-)-threo-5-amino-4-phenyl-1,3-dioxane 
• 56-75-7 chloramphenicol 
• 34718-53-1 (1R,2R)-3-dichloroacetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-ol 

Downstream Products

• 109162-23-4 (1RS,2SR)-1,3-diacetoxy-2-amino-1-(4-nitro-phenyl)-propane; hydrochloride 
• 109162-23-4 (1RS,2RS)-1,3-diacetoxy-2-amino-1-(4-nitro-phenyl)-propane; hydrochloride 
• 57409-60-6 {(S)-1-[(1R,2R)-2-Hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 7447-49-6 D-(-)-threo-1-(p-nitrophenyl)-2-(L-phenylalanylamido)-1,3-propanediol 
• 57409-59-3 {[(1R,2R)-2-Hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Interaction of chloramphenicol tripeptide analogs with ribosomes

Chloramphenicol amine peptide derivatives containing tripeptide fragments of regulatory “stop peptides”–MRL, IRA, IWP–were synthesized. The ability of the compounds to form ribosomal complexes was studied by displacement of the fluorescent erythromycin an

STEREOSELECTIVE SYNTHESIS OF (+/-)-threo-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

Addition of hypobromic acid to styrene afforded styrene bromohydrin (I) which was dehydrated to ω-bromostyrene (II).Prince reaction of II with aqueous formaldehyde gave 5-bromo-4-phenyl-1,3-dioxane (III).The bromine atom in III was replaced with amino group by treatment with methanolic ammonia at 150 deg C and 6 - 8 MPa and the obtained threo-5-amino-4-phenyl-1,3-dioxane (IVa) was hydrolyzed to give (+/-)-threo-2-amino-1-phenyl-1,3-propanediol (V).Suitably chosen method of nitration converted the free base IVa or its N-acetyl derivative IVb into 5-amino-4-(4-nitrophe nyl)-1,3-dioxane (VIa) or its N-acetyl derivative VIb which without isolation were hydrolyzed to threo-2-amino-1-(4-nitrophenyl)-1,3-propanediol (VII), isolated as hydrochloride.The liberated base was resolved into enantiomers and dichloroacetylated in the known manner to give D-(-)-threo-2-dichloroacetylamino-1-(4-nitrophenyl)-1,3-propanediol (chloramphenicol).