355402-96-9Relevant academic research and scientific papers
Synthesis and biological activity of N-acyl-5-bromanthranilic acids
Dolzhenko,Korkodinova,Kotegov,Vasilyuk,Novikova
, p. 418 - 420 (2006)
Ten N-acyl-5-bromanthranilic acids have been obtained via acylation of 5-bromanthranilic acid with appropriate anhydrides. The antiinflammatory and antibacterial properties of the synthesized compounds have been evaluated. It is established that N-(o-anisoyl)-5-bromanthranilic acid possesses most pronounced antiinflammatory activity (49% inhibition of carrageenan induced paw edema in rat) and antimicrobial properties (MIC = 2.0 μg/ml with respect to St. aureus and E. coli).
