35544-95-7

Basic information

• Product Name: (3aR,7aR)-3a-hydroxy-7a-methylperhydroindene-1,5-dione
• CAS NO: 35544-95-7
• Molecular Weight: 182.219
• Mol File: 35544-95-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (3aR,7aR)-3a-hydroxy-7a-methylperhydroindene-1,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,7aR)-3a-hydroxy-7a-methylperhydroindene-1,5-dione(35544-95-7)
• EPA Substance Registry System: (3aR,7aR)-3a-hydroxy-7a-methylperhydroindene-1,5-dione(35544-95-7)

Safety Data

• Hazardous Substances Data: 35544-95-7(Hazardous Substances Data)

Upstream product

• 765-69-5 2-Methylcyclopentane-1,3-dione 
• 78-94-4 methyl vinyl ketone 
• 25112-78-1 2-methyl-2-(3-oxobutyl)-1,3-cyclopentanedione 
• 344-25-2 D-Prolin 

Downstream Products

• 17553-86-5 (R)-7a-methyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione 
• 17553-86-5 (S)-Halos-Parish ketone 

Relevant articles and documents

AN APPROACH TO STEREOSELECTIVE FORMATION OF GLYCINOECLEPIN A SIDE CHAIN

Claisen rearrangement was found to be an efficient method for the stereoselective construction of the glycinoeclepin A side chain.

Evaluating β-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction

A systematic study of the effect of substitution within the β-amino acid framework indicates that both β2- and β3- amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained β-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to l-proline. The Royal Society of Chemistry.

Inotropic activity of hydroindene amidinohydrazones

Several hydroindenic derivatives (7a-methyl-2,3,5,6,7,7a-hexahydro-1H-indenes), bearing an amidinohydrazone at C-5 and different moieties at C-1, have been synthesized and evaluated for their inotropic and chronotropic effects on right- and left-guinea-pig-atria activity. Three of them showed the same profile as digoxin, although with lower potency. The effect on Na+,K+ ATPase (NKA) was also evaluated for these three compounds, observing that two of them, with the same absolute configuration as natural cardenolides, are also NKA inhibitors, while the compound with the opposite configuration lacks such an effect. More interestingly, both active compounds act without affecting the cardiac rhythm. This could be related to the selective inhibition of the human α2β1 isozyme (associated with the inotropic effect) with respect to the α1β1 isozyme (associated with the maintenance of basal ionic levels in the cell and the toxic effect of cardenolides).