3555-18-8Relevant academic research and scientific papers
Nitration method for p-alkylphenol
-
Paragraph 0073-0077, (2019/04/10)
The invention discloses a nitration method for p-alkylphenol. The nitration method successively comprises the following steps: 1) adding the p-alkylphenol used as a raw material into a container, thenadding water and a catalyst, dropwise adding nitric acid under stirring, controlling a temperature of materials in the container not to exceed 25 DEG C in the dropwise adding process, and after the nitric acid is dropwise added, carrying out a reaction at 10 to 20 DEG C for 2 to 3 h; and 2) subjecting a reaction solution obtained in the step 1) to standing and layering, wherein the lower layer obtained by layering is a product (o-nitro-p-alkylphenol), and subjecting an upper-layer solution obtained by layering to cyclic reuse, i.e., cyclic nitration. By adoption of the method for synthesizingthe o-nitro-p-alkylphenol provided by the invention, the utilization rate of raw materials is high; cyclic reuse of waste acid and waste water is realized; the discharging of three wastes is reduced;the cost of production is lowered; meanwhile, a product has high purity, high yield and good industrial application value.
Alkyl-substituted benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same
-
, (2008/06/13)
A novel rifamycin derivative having the formula (I): STR1 wherein X1 is an alkyl group with 1 to 6 carbon atoms or a cycloalkyl group with 3 to 8 carbon atoms; X2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; R1 is hydrogen atom or acetyl group; A is a group represented by the formula: STR2 wherein R2 is an alkyl group with 1 to 4 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms and R3 is an alkyl group with 1 to 6 carbon atoms or an alkoxyalkyl group with 2 to 6 carbon atoms, or a group represented by the formula STR3 wherein STR4 is a 3 to 9 membered cyclic amino group with 2 to 8 carbon atoms, R4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective ingredient. The rifamycin derivative of the present invention having the formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.
