35556-81-1

Basic information

• Product Name: 6-methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one
• Synonyms: 1,2,3,9-tetrahydro-6-methoxy-4H-Carbazol-4-one
• CAS NO: 35556-81-1
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.2478
• Mol File: 35556-81-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 420.8°C at 760 mmHg
• Flash Point: 208.3°C
• Density: 1.272g/cm³
• Vapor Pressure: 2.75E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 6-methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one(35556-81-1)
• EPA Substance Registry System: 6-methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one(35556-81-1)

Safety Data

• Hazardous Substances Data: 35556-81-1(Hazardous Substances Data)

Upstream product

• 36646-77-2 3-(4-methoxyphenylamino)cyclohex-2-en-1-one 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 504-02-9 1,3-cylohexanedione 
• 104-94-9 4-methoxy-aniline 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 5345-54-0 3-chloro-4-methoxyaniline 
• 153865-38-4 3-(3-Chloro-4-methoxy-phenylamino)-cyclohex-2-enone 

Downstream Products

• 88368-20-1 dihydro-6,7 methoxy-10 5H-pyrimidino<5,4-c>carbazole 
• 247096-44-2 9-benzyl-6-methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one 

Relevant articles and documents

Development of Novel VEGFR2 Inhibitors Originating from Natural Product Analogues with Antiangiogenic Impact

A novel natural small molecule, voacangine (Voa), has been discovered as a potent antiangiogenic compound. Notably, Voa directly binds the kinase domain of the vascular endothelial growth factor receptor 2 (VEGFR2) and thereby inhibits downstream signalin

Palladium-catalyzed synthesis of natural and unnatural 2-, 5-, and 7-oxygenated carbazole alkaloids from N-arylcyclohexane enaminones

A palladium-catalyzed synthesis of the carbazole framework is described, including the preparation of 2-, 5-, and 7-oxygenated natural and unnatural carbazole alkaloids. A series of N-arylcyclohexane enaminones, generated by condensation of cyclohexane-1,3-dione with diverse anilines, were aromatized by a Pd(0)-catalyzed thermal treatment to afford the corresponding diarylamines. The latter were submitted to a Pd(II)-catalyzed cyclization and methylation processes to provide the desired carbazoles, including clausine V. Following an inverse strategy, a new and short total synthesis of glycoborine is also reported.

AMINOALKOXY CARBAZOLES FOR THE TREATMENT OF CNS DISEASES

The present invention provides aminoalkoxy carbazole derivatives, and more specifically, provides compounds of formula (I) wherein R 1, R 2, R 3, R 4, R 8 and R 9 are described herein. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.