35566-43-9Relevant academic research and scientific papers
Naphthyl ketones: A new class of Janus kinase 3 inhibitors
Brown, George R.,Bamford, Andrea M.,Bowyer, Jonathan,James, Daniel S.,Rankine, Neil,Tang, Eric,Torr, Vanessa,Culbert, Eric J.
, p. 575 - 579 (2007/10/03)
Potent inhibition of Janus kinase 3 was found for a series of naphthyl(β-aminoethyl)ketones (e.g. 7, pIC50 = 7.1 ± 0.3). Further studies indicated that these compounds fragment in less than 1 h by retro-Michael reaction in the Jak3 in vitro ELISA assay procedure. The breakdown product of 7,2-naphthylvinyl ketone (22, pIC50 = 6.8 ± 0.3) showed very similar inhibitory activity to 7. Compounds 7 (in neutral buffer) and 22 will be useful pharmacological tools for the investigation of the Janus tyrosine kinase Jak3. (C) 2000 Elsevier Science Ltd. All rights reserved.
