10024-89-2

Basic information

• Product Name: MORPHOLINIUM CHLORIDE
• Synonyms: MORPHOLINIUM CHLORIDE;MORPHOLINE HYDROCHLORIDE;Morpholinhydrochlorid;Morphol Hydrochloride;Morpholinium hydrochloride;Morpholin hydrochloride
• CAS NO: 10024-89-2
• Molecular Formula: C₄H₁₀NO*Cl
• Molecular Weight: 123.58
• EINECS: 233-029-4
• Product Categories: API intermediates
• Mol File: 10024-89-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 204℃
• Boiling Point: 128.9 °C at 760 mmHg
• Flash Point: 35.6 °C
• Appearance: White or off-white crystal powder
• Density: 0.83g/cm3
• Vapor Pressure: 10.4mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Water Solubility: Soluble in water
• CAS DataBase Reference: MORPHOLINIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLINIUM CHLORIDE(10024-89-2)
• EPA Substance Registry System: MORPHOLINIUM CHLORIDE(10024-89-2)

Safety Data

• Hazardous Substances Data: 10024-89-2(Hazardous Substances Data)

Usage

Chemical Properties

White Crysstalline

InChI:InChI=1/C4H9NO.ClH/c1-3-6-4-2-5-1;/h5H,1-4H2;1H

Upstream product

• 110-91-8 morpholine 
• 67-66-3 chloroform 
• 1806-95-7 4-diethoxythiophosphorylsulfanyl-morpholine 
• 136001-43-9 5,5-dimethyl-2-(1-morpholino-1-phenylethyl)-2-oxo-1,3,2-dioxaphosphorinane 
• 1258431-65-0 1-(thien-2-yl)-3,4,4-trichloro-3-buten-1-one 
• 1258431-66-1 1-(4-hydroxyphenyl)-3,4,4-trichloro-3-buten-1-one 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 6339-26-0 4-tosylmorpholine 
• 10316-00-4 4-benzyl-morpholine 
• 698-16-8 benzohydroximoyl chloride 
• 13368-42-8 4-(trimethylsilyl)morpholine 
• 75-77-4 chloro-trimethyl-silane 
• 108-94-1 cyclohexanone 
• 63913-42-8 (3E)-4-morpholin-4-yl-pent-3-en-2-one 

Downstream Products

• 47332-32-1 1-[9]anthryl-3-morpholino-propan-1-one 
• 854433-88-8 4-methyl-2-morpholin-4-ylmethyl-cyclohexanone 
• 53756-65-3 2-morpholin-4-ylmethyl-1-phenyl-butan-1-one 
• 39067-47-5 2,2-dimethyl-3-morpholino-propan-1-ol 
• 23588-51-4 2,2-dimethyl-3-(N-morpholino)propanal 
• 3731-59-7 moroxydine 
• 2298-48-8 3-morpholin-4-yl-1-phenyl-propan-1-one 
• 100616-44-2 3-morpholin-4-yl-1-(4-nitro-phenyl)-propan-1-one 
• 58187-54-5 2-morpholin-4-ylmethyl-1-phenyl-propenone; hydrochloride 
• 78888-46-7 2-Morpholin-4-ylmethyl-1-(4-nitro-phenyl)-propenone; hydrochloride 
• 100596-00-7 1-(4-methoxyphenyl)-2-(1-morpholinomethyl)-2-propen-1-one hydrochloride 
• 126921-43-5 4-(2-Morpholin-4-yl-ethyl)-quinoline 
• 59566-50-6 N-[2-(2-pyridyl)ethyl]morpholine 
• 126921-47-9 1-(2-Morpholin-4-yl-ethyl)-isoquinoline 

Relevant articles and documents

Selenoxide elimination triggers enamine hydrolysis to primary and secondary amines: A combined experimental and theoretical investigation

We discuss a novel selenium-based reaction mechanism consisting in a selenoxide elimination-triggered enamine hydrolysis. This one-pot model reaction was studied for a set of substrates. Under oxidative conditions, we observed and characterized the formation of primary and secondary amines as elimination products of such compounds, paving the way for a novel strategy to selectively release bioactive molecules. The underlying mechanism was investigated using NMR, mass spectrometry and density functional theory (DFT).

A New Reagent for the Selective, High-Yield N-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine

Secondary amine hydrochlorides are obtained in high yield by reaction of tertiary amines with α-chloroethyl chloroformate followed by warming the intermediate carbamate in methanol.

Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol

Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications.

Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.