35567-30-7Relevant articles and documents
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
De Vrieze, Jana,Louage, Benoit,Deswarte, Kim,Zhong, Zifu,De Coen, Ruben,Van Herck, Simon,Nuhn, Lutz,Kaas Frich, Camilla,Zelikin, Alexander N.,Lienenklaus, Stefan,Sanders, Niek N.,Lambrecht, Bart N.,David, Sunil A.,De Geest, Bruno G.
, p. 15390 - 15395 (2019)
Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid–polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid–polymer amphiphiles for optimized lymphoid targeting.
Synthesis of lipid derivatives of pyrrole polyamide and their biological activity
Yamamoto, Masahiko,Zhu, Changjin,Yi, Lui,Rong, Zheng,Miura, Yoshie,Izumi, Minoru,Nakajima, Shuhei,Tanamoto, Ken-Ichi,Shimizu, Sakayu,Baba, Naomichi
, p. 1078 - 1082 (2008/02/04)
Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.
