35567-59-0

Basic information

• Product Name: 2-Methylbenzofuran-3(2H)-one
• Synonyms: 2-Methyl-3(2H)-benzofuranone;2-Methylbenzofuran-3(2H)-one;2-Methylcoumaran-3-one
• CAS NO: 35567-59-0
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.16
• Mol File: 35567-59-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methylbenzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylbenzofuran-3(2H)-one(35567-59-0)
• EPA Substance Registry System: 2-Methylbenzofuran-3(2H)-one(35567-59-0)

Safety Data

• Hazardous Substances Data: 35567-59-0(Hazardous Substances Data)

Upstream product

• 119-36-8 methyl salicylate 
• 133867-02-4 2-(1-Methoxycarbonyl-ethoxy)-benzoic Acid Methyl Ester 
• 5445-17-0 Methyl 2-bromopropionate 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 646522-85-2 trifluoromethanesulfonic acid 1-(2-hydroxyphenyl)propenyl ester 
• 646522-74-9 trifluoromethanesulfonic acid 2-propionylphenyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 31159-31-6 2-(2-hydroxyphenyl)-3-methylindole 

Relevant articles and documents

Hammet constants effects in microwave cascade etherification-cyclization- krapcho reaction to access [2,3]-dihydrobenzofuran-3-ones from salicylic derivatives

Two methods were evaluated for the synthesis of substituted [2,3]-dihydro-2-methyl-benzofuran-3-ones from corresponding salicylate esters under microwave irradiation. A two-step sequence via ether intermediates was convenient for various substituted salic

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Oxidative ring closure of alkyl-substituted 2-hydroxyacetophenone trifluoromethanesulfonate esters (triflates) occurs upon exposure to base in anaerobic DMF at 20-90 °C. Alkyl substitution is required for ring closure. A migrated enol triflate product forms at lower temperature in high yield via migration of the trifluoromethanesulfonate in the unsubstituted and monoalkyl-substituted cases. The alkyl-substituted enol triflates also enter into the benzofuran-3-one ring-forming process under thermal cyclization conditions. Potential mechanistic pathways are evaluated.