355809-03-9Relevant academic research and scientific papers
Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus
Di Grandi, Martin J.,Curran, Kevin J.,Feigelson, Gregg,Prashad, Amar,Ross, Adma A.,Visalli, Robert,Fairhurst, Jeanette,Feld, Boris,Bloom, Jonathan D.
, p. 4157 - 4160 (2004)
The preparation of α-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s0.1μM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS
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Page/Page column 68, (2016/05/19)
The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and may be useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
