Bioorganic and Medicinal Chemistry Letters p. 4157 - 4160 (2004)
Update date:2022-09-26
Topics:
Di Grandi, Martin J.
Curran, Kevin J.
Feigelson, Gregg
Prashad, Amar
Ross, Adma A.
Visalli, Robert
Fairhurst, Jeanette
Feld, Boris
Bloom, Jonathan D.
The preparation of α-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1μM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
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