355827-05-3 Usage
Uses
Used in Pharmaceutical Industry:
STK393606 is used as a research tool for studying the role of 15-hydroxy PGDH in the inactivation of prostaglandins and related eicosanoids. Its selectivity and potency make it a valuable compound for investigating the enzyme's function and potential therapeutic applications in various diseases and conditions.
Used in Drug Discovery:
STK393606 is used as a lead compound in the development of new drugs targeting 15-hydroxy PGDH. Its ability to selectively inhibit the enzyme's activity may lead to the discovery of novel therapeutic agents for treating diseases associated with altered prostaglandin levels.
Used in Enzyme Inhibition Studies:
STK393606 is used as an inhibitor in enzyme inhibition studies to understand the mechanism of action and kinetics of 15-hydroxy PGDH. This information can be crucial for optimizing the design of new inhibitors and drugs targeting this enzyme.
Used in Biochemical Assays:
STK393606 is used in biochemical assays to measure the activity of 15-hydroxy PGDH and assess the effectiveness of other potential inhibitors. This can help in the development of new drugs and therapies targeting this enzyme.
target
nad+-dependent type-i 15-hydroxy pgdh
IC 50
26.4 nm
references
[1] niesen f h, schultz l, jadhav a, et al. high-affinity inhibitors of human nad + -dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships[j]. plos one, 2010, 5(11).[2] tai h, ensor c m, tong m, et al. prostaglandin catabolizing enzymes.[j]. prostaglandins & other lipid mediators, 2002: 483-493.[3] lee s c, levine l. prostaglandin metabolism. ii. identification of two 15-hydroxyprostaglandin dehydrogenase types.[j]. journal of biological chemistry, 1975, 250(2): 548-552.
Check Digit Verification of cas no
The CAS Registry Mumber 355827-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,5,8,2 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 355827-05:
(8*3)+(7*5)+(6*5)+(5*8)+(4*2)+(3*7)+(2*0)+(1*5)=163
163 % 10 = 3
So 355827-05-3 is a valid CAS Registry Number.