3560-47-2

Upstream product

• 104496-47-1 N-tosyl-N-[2-(tosylamino)ethyl] acetamide 
• 108-55-4 glutaric anhydride, 
• 14316-16-6 N-tosylethylenediamine 
• 75-36-5 acetyl chloride 

Downstream Products

• 126411-72-1 4-tosyl-3,4,5,6-tetrahydro-2H-<1,4,7>benzoxadiazecine hydrochloride 
• 126411-69-6 N-tosyl-N-2-<2-(1,3-dioxolan-2-yl)phenoxyethyl>ethylenediamine 
• 126440-70-8 4-tosyl-3,4,5,6,7,8-hexahydro-2H-<1,4,7>benzoxadiazecine 
• 126411-68-5 N-acetyl-N'-tosyl-N'-2-<2-(1,3-dioxolan-2-yl)phenoxyethyl>ethylenediamine 

Relevant academic research and scientific papers

Preparation method and application of suvorexant intermediate

The invention provides a preparation method and application of a suvorexant intermediate, and relates to the technical field of chemical synthesis. The preparation method of the suvorexant intermediate comprises the following step: (e) reacting a compound as shown in a formula IV under the action of a Grubbs catalyst to obtain a compound as shown in a formula V. The Grubbs catalyst (Grubbs second-generation catalyst) is creatively used for construction of the suvorexant intermediate seven-membered nitrogen-containing chiral heterocycle, an inflammable and highly toxic compound methyl vinyl ketone is not needed, inflammable and explosive toxic gas is not needed, reaction is not needed under the conditions of strong acid, strong alkali and high temperature, generation of a large amount of acid liquor and alkali liquor and high-temperature operation can be avoided, the method is mild in reaction condition, environment-friendly, high in safety coefficient and easy to industrialize.

Metal-free synthesis of activated ynesulfonamides and tertiary enesulfonamides

An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described. Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at room temperature. Likewise, terminal alkynes react with sulfonylamides to provide enesulfonamides. Z/E enesulfonamides can be transformed exclusively into E enesulfonamides.

Photochemical desulfonylation of N-tosyl amides by 2-phenyl-N,N′- dimethylbenzimidazoline (PDMBI)

Photoinduced electron transfer reaction between N-tosyl amides and 2-phenyl-N,N′-dimethylbenzimidazoline (PDMBI) provides an efficient approach for the desulfonylation of N-tosyl amides. Georg Thieme Verlag Stuttgart.