35601-91-3Relevant academic research and scientific papers
Differential functional theory and molecular docking studies of newly synthesized carbamates
Danish, Muhammad,Raza, Muhammad A.,Anwar, Uzma,Rashid, Umer,Ahmed, Zaheer
, p. 1408 - 1415 (2019/05/15)
Four new carbamates (RZ1–RZ4) were synthesized from different amine moieties through reported methods. The reaction was monitored using thin layer chromatography and characterization was done using m.p., fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) techniques. Density functional theory (DFT) studies were carried out using Gaussian 09 software to compare the theoretical and practical parameters of the synthesized compounds. Highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) were also drawn to calculate the energy difference between orbitals. In-vitro enzyme inhibition potential against acetylcholine esterase (AChE), butyrylcholine esterase (BChE), and protease was checked through standard protocols that suggested moderate inhibition against selected enzymes. Docking studies were also carried out, which depicted that these compounds have ability to bind on the active site of AChE and BChE.
Palladium-Catalyzed Decarboxylative Synthesis of Arylamines
Dai, Qipu,Li, Peihe,Ma, Nuannuan,Hu, Changwen
supporting information, p. 5560 - 5563 (2016/11/17)
A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.
1,7-palladium migration via C-H activation, followed by intramolecular amination: Regioselective synthesis of benzotriazoles
Zhou, Jun,He, Jianjun,Wang, Binjie,Yang, Weijun,Ren, Hongjun
supporting information; experimental part, p. 6868 - 6870 (2011/06/21)
A novel 1,7-palladiummigration-cyclization-dealkylation sequence for the regioselective synthesis of benzotriazoles has been developed. These reactions proceed in excellent yields with high regioselectivities. The mechanism of the reaction has also been investigated.
Dibutyltin oxide catalyzed aminolysis of oxalate to carbamate, oxamate and derivatives of imidazolidine trione
Kunde, Lalita B.,Kalyani, Vishwanath S.,Gupte, Sunil P.
experimental part, p. 402 - 407 (2010/08/06)
Catalytic aminolysis of oxalates by simple and substituted ureas has been shown to give carbamates, oxamates and derivatives of imidazolidine trione. Various substituted ureas and oxalates were screened to verify the applicability of the protocol. The rol
Unexpected Reaction of Oximinoacetoacetate with Amines: A Novel Synthesis of Carbamates
Elghamry, Ibrahim
experimental part, p. 3010 - 3015 (2009/12/01)
The synthesis of alkyl carbamates by a solvent-free reaction of oximinoacetoacetate and amine at 130C is reported. A preliminary mechanism to this unexpected reaction is also given.
Microwave promoted solvent-free one-pot synthesis of N,N′- disubstituted urea derivatives
Jadhav, Vinod H.,Deshpande, Shubhada S.,Borate, Hanumant B.,Wakharkar, Radhika D.
, p. 205 - 208 (2007/10/03)
An efficient one-pot synthesis of N,N′-disubstituted urea derivatives from substituted anilines, ethyl chloroformate and methyl anthranilate or methyl 3-amino-2-butenoate under microwave irradiation is reported.
Preparation and applications of a polymer-supported phosphoryl azide
Lu, Yuhua,Taylor, Richard T.
, p. 9267 - 9269 (2007/10/03)
A polymer-supported diphenylphosphoryl azide was prepared. This polymer-supported version of DPPA is useful due to its lower toxicity, moisture tolerance and ease of workup after reaction. The synthetic application of this solid-phase reagent was explored by conversion of a variety of carboxylic acids to urethanes and ureas through Curtius rearrangement reactions. Carboxylic acids bearing different functional groups (aromatic, aliphatic and heterocyclic carboxylic acids) were subjected to the reaction. The corresponding products were isolated with satisfactory yields.
PLATINUM COMPLEX CATALYZED REDUCTIVE N-CARBONYLATION OF NITROARENES TO THE CARBAMATES.
Watanabe,Tsuji,Takeuchi,Suzuki
, p. 3343 - 3348 (2007/10/02)
The platinum catalyst combined with triphenylphosphine, tin(IV) chloride, and triethylamine showed high activity for the reductive N-carbonylation of nitroarene in ethanol at 180 degree C under carbon monoxide of 60 kg cm** minus **2. From nitrobenzene, ethyl phenylcarbamate was obtained in 83% yield. Iron(III) chloride, aluminum chloride and titanium(IV) chloride could be used as Lewis acids in place of tin(IV) chloride. Various nitroarenes were transformed into corresponding carbamate in moderate to excellent yields with the platinum catalyst.
