56836-51-2Relevant academic research and scientific papers
Palladium catalyzed Csp2-H activation for direct aryl hydroxylation: The unprecedented role of 1,4-dioxane as a source of hydroxyl radicals
Seth, Kapileswar,Nautiyal, Manesh,Purohit, Priyank,Parikh, Naisargee,Chakraborti, Asit K.
supporting information, p. 191 - 194 (2015/01/09)
A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp2-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups.
Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates
Mahy, William,Plucinski, Pawel K.,Frost, Christopher G.
supporting information, p. 5020 - 5023 (2015/01/08)
An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.
General and efficient synthesis of benzoxazol-2(3H)-ones: Evolution of their anti-cancer and anti-mycobacterial activities
Indrasena Reddy,Aruna,Sudhakar Babu,Vijayakumar,Manisha,Padma Sridevi,Yogeeswari,Sriram
, p. 59594 - 59602 (2015/02/19)
A novel class of benzo[d]oxazol-2(3H)-one derivatives has been synthesized and their in vitro cytotoxicity against human pancreatic adenocarcinoma and human non-small cell lung carcinoma cancer cell lines was evaluated. Many of these compounds were found to display excellent to moderate activity. Among them, 6b, 6l, 6n and 6x were identified as lead molecules. In particular, 6l and 6n were found to be potent against the pancreatic adenocarcinoma cell line whereas the 6x was found to be effective against the human non-small cell lung carcinoma cell line. Conversely, the compounds 6l-x were found to be ineffective against Mycobacterium tuberculosis. Of the various molecules, 6h showed promising anti-mycobacterial activity, with an IC50 value equal to that of ciprofloxacin.
Microwave promoted solvent-free one-pot synthesis of N,N′- disubstituted urea derivatives
Jadhav, Vinod H.,Deshpande, Shubhada S.,Borate, Hanumant B.,Wakharkar, Radhika D.
, p. 205 - 208 (2007/10/03)
An efficient one-pot synthesis of N,N′-disubstituted urea derivatives from substituted anilines, ethyl chloroformate and methyl anthranilate or methyl 3-amino-2-butenoate under microwave irradiation is reported.
Synthesis of Carbamates Using Yttria-Zirconia Based Lewis Acid Catalyst
Pandey, Rajesh K.,Dagade, Sharda P.,Dongare, Mohan K.,Kumar, Pradeep
, p. 4019 - 4027 (2007/10/03)
A variety of amines react with chloroformates in the presence of catalytic amount of yttria-zirconia based catalyst to afford the corresponding carbamates in excellent yields.
Ultrasound promoted 'one pot' conversion of nitrocompounds to carbamates
Chandrasekhar,Narsihmulu,Jagadeshwar
, p. 771 - 772 (2007/10/03)
An efficient ultrasound promoted novel direct conversion of nitro compounds to N-(tert-butoxycarbonyl) amines and N-(ethoxycarbonylamines) is achieved using Sn-NH4Cl for the first time.
Reaction of 2-hydrazinobenzoxazole with 1,3-diketones: Formation of some unexpected products
Singh, S. P.,Kumar, Dalip,Kumar, Devinder,Kapoor, R. P.
, p. 682 - 685 (2007/10/03)
Treatment of 2-hydrazinobenzoxazole (1) with several trifluoromethylated 1,3-diketones (2) furnishes the intermediate pyrazolines (3) instead of the expected pyrazoles.Attemps to dehydrate 3 using strong acids result in the cleavage of benzoxazole ring.Such a ring cleavage is also observed when 1 is treated with non-fluorinated 1,3-diketones (4) giving three products (5-7) whose formation has been rationalized through a plausible mechanism.Many benzoxazolylpyrazoles (8) have been eventually synthesised and the planarity of these molecules established by 1H NMR spectroscopy.
Synthesis and structure-activity relationships of new β-adrenoreceptor antagonists. Evidence for the electrostatic requirements for β-adrenoreceptor antagonists
Kettmann,Csollei,Racanska,Svec
, p. 843 - 851 (2007/10/02)
A series of mono- and disubstituted phenoxypropanolamines, structurally related to practolol and acebutolol, has been synthesized and tested for β-adrenoreceptor blocking activity. Structure-activity relationships are discussed. The reasons for the lack of activity of compounds 3n and 4n have also been examined. The results suggest that the negative electrostatic potential above the phenyl ring of phenoxypropanolamines is essential for binding activity and point to the presence of an electropositive residue in the β-adrenoreceptor binding site.
