356072-46-3

Basic information

• Product Name: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE
• Synonyms: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE;Spiro[3H-indole-3,4'-piperidin]-2(1H)-one, hydrochloride (1:1);Spiro[3H-indole-3,4'-piperidin]-2(1H)-one, hydrochloride;1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] hydrochloride;1,2-Dihydrospiro[indole-3,4'-piperidine]-2-one hydrochloride
• CAS NO: 356072-46-3
• Molecular Formula: C₁₂H₁₄N₂O*ClH
• Molecular Weight: 238.7133
• Mol File: 356072-46-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE(356072-46-3)
• EPA Substance Registry System: SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE(356072-46-3)

Safety Data

• Hazardous Substances Data: 356072-46-3(Hazardous Substances Data)

Usage

Description

SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE is a complex organic compound that features a unique spiro structure, which consists of an indoline and a piperidine moiety connected through a carbonyl bridge. SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE is known for its high affinity and selectivity as a σ ligand, making it a valuable entity in the field of medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical Research:
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE is used as a high-affinity, selective σ ligand for the development of novel therapeutic agents. Its unique binding properties to σ receptors can be leveraged to explore its potential in treating various neurological and psychiatric disorders, as well as other conditions where σ receptor modulation may be beneficial.
Used in Drug Discovery:
In the realm of drug discovery, SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE serves as a valuable lead compound. Its structural features and σ ligand properties can be further optimized and modified to develop more potent and selective drugs targeting specific σ receptor subtypes, thereby enhancing the therapeutic potential and reducing side effects.
Used in Chemical Synthesis:
SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE HYDROCHLORIDE can also be utilized as a key intermediate in the synthesis of other complex organic molecules and pharmaceuticals. Its unique spiro structure and functional groups provide a versatile platform for chemical modifications, enabling the creation of a diverse range of compounds with potential applications in various industries.

Upstream product

• 252882-60-3 tert-butyl 2-oxo-1,2-dihydro-1'H-spiro[indole-3,4-piperidine]-1'-carboxylate 
• 356072-45-2 1'-benzyloxycarbonylspiro[indoline-3,4'-piperidine]-2-one 

Relevant articles and documents

SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.