35614-21-2

Usage

InChI:InChI=1/C15H10O4/c16-13(17)8-9-4-3-6-11-14(18)10-5-1-2-7-12(10)19-15(9)11/h1-7H,8H2,(H,16,17)

Upstream product

• 26539-21-9 4-(bromomethyl)-9H-xanthen-9-one 
• 5396-28-1 4-methylxanthen-9-one 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 88-67-5 2-Iodobenzoic acid 
• 54182-77-3 (9-Oxo-9H-xanthen-4-yl)-acetonitrile 
• 90-47-1 xanth-9-one 
• 546-67-8 lead(IV) tetraacetate 

Downstream Products

• 134940-11-7 N-[2-(9-Oxo-9H-xanthen-4-yl)-acetyl]-benzenesulfonamide 
• 5396-28-1 4-methylxanthen-9-one 

Relevant academic research and scientific papers

Photodecarboxylation of xanthone acetic acids: C-C bond heterolysis from the singlet excited state

Irradiation of 2- and 4-xanthone acetic acid in aqueous buffer (pH 7.4) leads to efficient (Φ = 0.67 and 0.64, respectively) photodecarboxylation to give the corresponding methyl products, consistent with an intermediate benzylic carbanion. Fluorescence a

Cancerous metastasis inhibitor

A chimeric protein wherein HI-8 which is the C-terminal domain of human urinary trypsin inhibitor (UTI) having a cancer cell metastasis inhibitory effect, is linked to a peptide containing the G domain of urokinase binding specifically to urokinase receptor expressed in a large amount in cancer cells.

Potential Antitumor Agents. 58. Synthesis and Structure-Activity Relationships of Substituted Xanthenone-4-acetic Acids Active against the Colon 38 Tumor in Vivo

In a search for compounds related to flavoneacetic acid with activity against solid tumors, a series of methyl- methoxy-, chloro, nitro-, and hydroxy-substituted xanthenone-4-acetic acids have been synthesized and evaluated against subcutaneously implanted colon adenocarcinoma 38 in vivo, using a short-term histology assay as a primary screening system.A major goal of this work was to identify compounds with similar profiles of activity to that of flavoneacetic acid but of higher potency.The level of activity of the compounds appeared to depend more on the nature of the substituent than its positioning, in the order Cl > Me, OMe > NO2, OH.However, the potency of the compounds was related much more to the position rather than the nature of the substitution, with 5-substituted compounds being clearly the most dose potent. 5-Methylxanthenone-4-acetic acid has a similar level of activity to that of flavoneacetic acid in the test systems employed but is more than 7-fold as does potent.

Oxidation of 9-Xanthenones with Lead(IV) Acetate. Formation of Di-γ-lactones

The oxidation of 9-xanthenones with lead (IV) acetate afforded 3a,3b,6a,12b-tetrahydro-2H-difuroxanthene-2,5,7(3H,6H)-triones in addition to other products.Characterization of the di-γ-lactones and the difference between the oxidation reaction of lead(IV) and manganese(III) acetates in the 9-xanthenone system are discussed.