35628-40-1

Upstream product

• 39061-98-8 5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepine-2-thione 
• 144-55-8 sodium hydrogencarbonate 
• 59077-25-7 2-chloro-2'-(3-chloromethyl-5-methyl-[1,2,4]triazol-4-yl)-benzophenone 

Relevant academic research and scientific papers

Methods for the production of 4H-s-triazolo[4,3-a][1,4]benzodiazepine 5N-oxides

The title compounds are prepared by reacting a 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazoline with a reactive derivative of a halogenoacetic acid, reacting the resultant halogenoacetyl derivative with a weak acid, reacting the resultant 2-(3-halomethyl-s-triazol-4-yl)benzophenone with hydroxylamine and subjecting the resultant 2-(3-hydroxyamino-methyl-s-triazol-4-yl)benzophenone to dehydration to effect ring closure.

6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine

6-(o-halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepines of the following formula: STR1 wherein the substituent "Hal" is either of the halogens having an atomic number up to 35, inclusive, i.e., fluoro, chloro or bromo, and their pharmacologica