35628-48-9

Upstream product

• 364046-84-4 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 

Downstream Products

• 82294-23-3 N-(3-Chloro-phenyl)-N'-[5-(2-chloro-phenyl)-7-nitro-3H-benzo[e][1,4]diazepin-2-yl]-hydrazine 
• 67974-50-9 2-(2-dimethylaminoethylthio)-5-(2-chlorophenyl)-7-nitro-3H-1,4-benzodiazepine 
• 1255209-57-4 C₂₂H₁₄ClN₃O₂S 
• 1255209-54-1 C₁₇H₁₂ClN₃O₂S 
• 303197-21-9 C₂₀H₁₃ClN₄O₂S 
• 1255209-59-6 C₂₁H₁₃ClN₄O₂S 
• 1255209-60-9 C₂₁H₁₃ClN₄O₂S 
• 80861-88-7 7-nitro-2-(3-chlorophenylcarbamoyloxyamino)-5-(2-chlorophenyl)-3H-1,4-benzodiazepine 

Relevant academic research and scientific papers

Pyrazolobenzodiazepines: Part I. Synthesis and SAR of a potent class of kinase inhibitors

A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK2 activity in vitro, and block cell cycle progression in human tumor cell lines. Further exploration has revealed that this class of compounds inhibits several kinases that play critical roles in cancer cell growth and division as well as tumor angiogenesis. Together, these properties suggest a compelling basis for their use as antitumor agents.

2-(2-Alkynylamino)-3H-1,4-benzodiazepines

Novel 6-substituted 4H-imidazo[1,2-a][1,4]benzodiazepines, the intermediate 5-substituted-2-(2-alkynylamino)-3H-1,4-benzodiazepines, pharmacologically acceptable acid addition salts thereof, and processes for their production. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are central nervous system depressants. They are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants, and also as feed additives for increasing growth rate and feed efficiency of livestock and poultry, milk production in the mammalian species and egg production in avian species.