364046-84-4

Upstream product

• 17714-02-2 2-aminoacetamido-2'-chloro-5-nitrobenzophenone 
• 17420-30-3 5-nitroanthranilonitrile 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 2011-66-7 2'-chloro-5-nitro-2-aminobenzophenone 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 52130-87-7 2-bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide 
• 10073-89-9 2-methyl-6-nitro-4H-benzo[d][1,3]oxazin-4-one 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 67974-50-9 2-(2-dimethylaminoethylthio)-5-(2-chlorophenyl)-7-nitro-3H-1,4-benzodiazepine 
• 4959-17-5 7-Aminoclonazepam 
• 2011-66-7 2'-chloro-5-nitro-2-aminobenzophenone 
• 5527-71-9 1-methyl-5-(2'-chloro-phenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one 
• 1334109-39-5 1-(12-bromododecyl)-5-(2-chlorophenyl)-7-nitro-1H-benzo[1,4]diazepin-2-one 
• 1381840-72-7 C₁₈H₁₄ClN₃O₃ 
• 1381840-73-8 C₂₂H₁₆ClN₃O₃ 
• 1381840-74-9 C₁₉H₁₆ClN₃O₅ 
• 1381840-75-0 C₁₈H₁₄ClN₃O₅ 
• 145741-24-8 C₁₇H₁₂ClN₃O₅ 
• 35628-48-9 7-nitro-1,3-dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiazepine-2-thione 
• 24139-70-6 11b-(2-chloro-phenyl)-10-nitro-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 
• 59349-86-9 5-(2-chlorophenyl)-2-[bis(morpholino)phosphinyloxy]-7-nitro-3H-1,4-benzodiazepine 

Relevant academic research and scientific papers

Method for synthesizing clonazepam compound

The invention discloses a method for synthesizing a clonazepam compound, and belongs to the technical field of organic chemical synthesis, and the preparation method comprises the following steps: by taking 2-amino-4-nitrophenyl potassium trifluoroborate as an initial raw material, carrying out oxidative coupling, amidation, affinity substitution reaction, intramolecular condensation reaction and the like to obtain a target compound; the method disclosed by the invention is short in synthesis step, safe to operate and simple and convenient in post-treatment, and the product can be obtained by directly filtering and leaching without other purification; only conventional acid, alkali and solvents are used in the whole reaction process, the cost is low, and the yield is increased by 30% or above.

Method for synthesizing 7-amino clonazepam compound

The invention discloses a method for synthesizing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-cyano-4-nitroaniline serves as an initial raw material, and a target compound is obtained through oxidative coupling, amidation, affinity substitution reaction, intramolecular Wittig reaction, reduction reaction and other processes. According to the invention, a brand new synthetic route is provided for 7-amino nitrazepam, the method has the advantages of short synthetic steps, safe operation and simple post-treatment, only conventional acid-base and solvent are used in the whole reaction process, the cost is low, and the yield is increased by more than 20%.

Novel method for preparing 7-amino clonazepam compound

The invention discloses a novel method for preparing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-amino-4-nitrobenzoic acid serves as an initial raw material, and a target compound is obtained through the processes of acetyl-lactonization, Grignard reaction, amide hydrolysis, intramolecular condensation reaction, reduction and the like. The method provided by the invention is safe to operate, avoids the use of heavy metals, is simple and convenient in post-treatment, can obtain the product through direct filtration and recrystallization, and does not need other purification. Only conventional acid, alkali and solvents are used in the whole reaction process, so that the method is less in environmental pollution, low in cost and higher in yield.

Process for preparing benzodiazepines

1,4-Benzodiazepin-2-ones are prepared via the reaction of a haloacetamidophenyl ketone with hexamethylenetetramine in the presence of ammonia. The 1,4-benzodiazepin-2-ones so prepared are known compounds useful as muscle relaxant and anti-convulsant agents.