356535-39-2Relevant academic research and scientific papers
Solution phase synthesis of ISIS 2922 (Vitravene) by the modified H-phosphonate approach
Reese, Colin B.,Yan, Hongbin
, p. 2619 - 2633 (2007/10/03)
The synthesis of Vitravene, a 21-mer oligonucleotide phosphorothioate (d[Gp(s)Cp(s)Gp(s)Tp(s)Tp(s)Tp(s)Gp(s)Cp(s)-Tp(s)Cp(s)Tp(s)Tp(s)Cp(s)Tp(s)Tp(s)C p(s)Tp(s)Tp(s)Gp(s)Cp(s)G]) by the modified H-phosphonate approach in solution is reported. The syntheti
