356535-50-7

Upstream product

• 108-95-2 phenol 
• 528569-40-6 5'-O-(4,4'-dimethoxytrityl)-4-O-phenylthymidine 
• 356535-49-4 3'-O-levulinyl-4-O-phenylthymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 40608-06-8 levulinic anhydride 
• 356535-36-9 N-[(2-cyanoethyl)sulfanyl]succinimide 

Downstream Products

• 356535-38-1 4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Solution phase synthesis of ISIS 2922 (Vitravene) by the modified H-phosphonate approach

The synthesis of Vitravene, a 21-mer oligonucleotide phosphorothioate (d[Gp(s)Cp(s)Gp(s)Tp(s)Tp(s)Tp(s)Gp(s)Cp(s)-Tp(s)Cp(s)Tp(s)Tp(s)Cp(s)Tp(s)Tp(s)C p(s)Tp(s)Tp(s)Gp(s)Cp(s)G]) by the modified H-phosphonate approach in solution is reported. The syntheti