356552-80-2Relevant academic research and scientific papers
Thiophene containing trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis
Singh, Priyanka,Manna, Sudipta Kumar,Jana, Amit Kumar,Saha, Tiash,Mishra, Pankaj,Bera, Saurav,Parai, Maloy Kumar,Srinivas Lavanya Kumar,Mondal, Sankalan,Trivedi, Priyanka,Chaturvedi, Vinita,Singh, Shyam,Sinha, Sudhir,Panda, Gautam
, p. 357 - 368 (2015/04/14)
Triarylmethanes (TRAMs) and thiophene containing trisubstituted methanes (TRSMs) have been reported by us, having potential against Mycobacterium tuberculosis and Mycobacterium fortuitum strains, respectively. Further, extension through synthesis and biol
Design, synthesis and antitubercular activity of compounds containing Aryl and heteroaryl groups with alkylaminoethyl chains
Panda, Gautam,Parai, Maloy Kumar,Srivastava, Ajay Kumar,Chaturvedi, Vinita,Manju,Sinha, Sudhir
scheme or table, p. 1121 - 1127 (2009/12/26)
Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37RV and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubcrcular activity. Among heteroaryl containing triarylmcthanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.
Thiophene containing triarylmethanes as antitubercular agents
Parai, Maloy Kumar,Panda, Gautam,Chaturvedi, Vinita,Manju,Sinha, Sudhir
, p. 289 - 292 (2008/09/18)
A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-12.5 μg/mL in vitro.
