356560-89-9

Usage

Type of Compound

Ketone

Structure

Contains a benzo[d][1,3]dioxole ring fused to a pyridine ring

Pharmaceutical Research

Used in the study of potential biological activities

Drug Discovery

Investigated for its potential as an anti-cancer agent and treatment for Alzheimer's disease

Medicinal Chemistry

Utilized as a building block for the synthesis of various organic compounds

Unique Features

a. Valuable compound for further research and development
b. Potential biological activities make it an interesting subject for study
c. Unique structure contributes to its potential applications in the pharmaceutical industry

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 6951-08-2 ethyl 1,3-benzodioxole-5-carboxylate 
• 147030-72-6 benzo[1,3]dioxole-5-carboxylic acid methoxymethylamide 
• 326-56-7 methyl 3,4-methylenedioxybenzoate 

Downstream Products

• 356560-76-4 1-(benzo[1,3]dioxol-5-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione 
• 752260-31-4 1-(benzo[1,3]dioxol-5-yl)-2-bromo-2-(6-methylpyridin-2-yl)ethanone 
• 710946-97-7 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-ylmethyl]-benzonitrile 
• 710947-09-4 4-[4-benzo[1,3]dioxol-5-yl-5-(6-methyl-pyridin-2-yl)-[1,2,3]triazol-2-yl]-benzonitrile 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-β type1 receptor kinase inhibitors

A series of 5-(pyridin-2-yl)thiazoles (14a-l and 15a-l) has been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 3-[[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)thiazol-2-ylamino]methyl ]b

Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 4(5)-(6-alkylpyridin-2-yl)imidazoles 13a-p, 17a, and 17b have been synthesized and evaluated for ALK5 inhibitory activity in an enzyme assay and in cell-based luciferase reporter assays. The quinoxalinyl analogue 13e inhibited ALK5 phosphoryla

Tri-substituted heteroaryls and methods of making and using the same

Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).

NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR

Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

Novel fused heteroaromatic compounds as transforming growth factor (TGF) inhibitors

Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.