35657-08-0

Basic information

• Product Name: Benzene, 1-(chloromethoxy)-4-methoxy-
• Synonyms: p-methoxyphenoxymethyl chloride;1-chloromethoxy-4-methoxy-benzene;p-methoxyphenyloxychloromethane;1-Chlormethoxy-4-methoxy-benzol
• CAS NO: 35657-08-0
• Molecular Formula: C8H9ClO2
• Molecular Weight: 172.611
• Mol File: 35657-08-0.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(chloromethoxy)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(chloromethoxy)-4-methoxy-(35657-08-0)
• EPA Substance Registry System: Benzene, 1-(chloromethoxy)-4-methoxy-(35657-08-0)

Safety Data

• Hazardous Substances Data: 35657-08-0(Hazardous Substances Data)

Upstream product

• 150-78-7 1,4-dimethoxybezene 
• 121824-41-7 1-methoxy-4-<(methylthio)methoxy>benzene 
• 150-76-5 4-methoxy-phenol 
• 121824-48-4 1-methoxy-4-((methylsulfinyl)methoxy)benzene 

Downstream Products

• 124068-42-4 1-(1,5-Dimethyl-hex-4-enyloxymethoxy)-4-methoxy-benzene 
• 124068-44-6 2-[(E)-6-(4-Methoxy-phenoxymethoxy)-3,7-dimethyl-octa-2,7-dienyloxy]-tetrahydro-pyran 
• 142041-42-7 bis<(4-methoxyphenoxy)methyl>diphenylphosphonium chloride 
• 142041-43-8 <(4-methoxyphenyl)methyl>diphenylphosphine oxide 
• 152984-35-5 (1S,2S,4R)-2-<(R)-3-(Benzyloxy)-1-cyclohexen-1-yl>-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152898-47-0 (1S,2S,4R)-2-<(R)-3-(Benzyloxy)-1-cyclohexen-1-yl>-1-<(Z)-2-(p-methoxy-phenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152984-37-7 (1S,2S,4R)-2-<(S)-3-(Benzyloxy)-1-cyclohexen-1-yl>-1-<(Z)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152984-42-4 (1S,2S,4R)-2-<(S)-3-(Methoxymethoxy)-1-cyclohexen-1-yl>-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152898-51-6 (1S,2S,4R)-2-<(S)-3-(Methoxymethoxy)-1-cyclohexen-1-yl>-1-<(Z)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152984-40-2 (1S,2S,4R)-2-<(R)-3-(Methoxymethoxy)-1-cyclohexen-1-yl>-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152984-38-8 (1S,2S,4R)-2-<(R)-3-(Methoxymethoxy)-1-cyclohexen-1-yl>-1-<(Z)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol 
• 152984-34-4 (1S,4R)-1-<(E)-2-(p-Methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanone 
• 152898-45-8 (1S,4R)-1-<(Z)-2-(p-Methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanone 

Relevant articles and documents

Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability com

p-Anisyloxymethyl Group, a Novel Oxidatively Removable Acetal Type OH-Protecting Group

Protection of various types of alcohols with p-anisyloxymethyl (p-AOM) chloride gave the corresponding p-AOM ethers which were deprotected with ceric ammonium nitrate efficiently.Chemoselective removal either of p-AOM group or of tetrahydropyranyl group is also reported.

Syntheses of Sulfinylmethyl Ethers and Conversion of these into Halomethyl and Acyloxymethyl Ethers

Halomethyl ethers can be prepared from sulfinyl ethers by cleavage of the carbon-sulfur bond with thionyl chloride, acetyl chloride or trimethylsilyl halides.In the presence of alkenyl groups in the substrate, acetyl chloride is the reagent of choice.Trifluoroacetic anhydride reacts in the same manner to form the trifluoroacetoxymethyl ether.With acetic anhydride, catalysis by methanesulfonic acid was required.At elevated temperatures in the presence of sodium acetate the products were formed by the Pummerer rearrangement.

5-Fluorouracil derivatives

5-Fluorouracil derivatives and a process for their preparation are provided. The 5-fluorouracil derivatives according to the invention have the general formula: STR1 R1 and R2 are the same or different and are hydrogen or STR2 with the proviso that both R1 and R2 are not hydrogen at the same time. A1, A2 and A3 are independently selected from hydrogen, and optionally substituted alkoxy and phenyloxy; at least one of A1, A2 and A3 being other than hydrogen. The 5-fluorouracil derivative is prepared by condensing 5-fluorouracil with a halide of the formula: STR3 in the presence of a base. The 5-fluorouracils according to the invention show anti-tumor activity.