356578-31-9

Basic information

• Product Name: 2(1H)-Pyridinone, 1-[(4-methoxyphenyl)methyl]-3-nitro-
• CAS NO: 356578-31-9
• Molecular Formula: C13H12N2O4
• Molecular Weight: 260.249
• Mol File: 356578-31-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyridinone, 1-[(4-methoxyphenyl)methyl]-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 1-[(4-methoxyphenyl)methyl]-3-nitro-(356578-31-9)
• EPA Substance Registry System: 2(1H)-Pyridinone, 1-[(4-methoxyphenyl)methyl]-3-nitro-(356578-31-9)

Safety Data

• Hazardous Substances Data: 356578-31-9(Hazardous Substances Data)

Upstream product

• 6332-56-5 3-nitropyridone 
• 824-94-2 p-methoxybenzyl chloride 
• 6332-56-5 2-hydroxy-3-nitropyridine 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 356578-37-5 3-[2'-(S)-(1'''-naphthylacetyl)amino-3'-(4''-methoxycarbonylmethyl)benzene]propanoylamino-1-(4-methoxybenzyl)-2-pyridone 
• 356578-33-1 3-[2'-(S)-t-butoxycarbonylamino-3'-(4''-methoxycarbonylmethyl)benzene]propanoylamino-1-(4-methoxybenzyl)-2-pyridone 
• 503618-67-5 ethyl 5H-5-p-methoxybenzyl-4-oxopyrrolo[5,6-c]pyridine-1-carboxylate 
• 356578-32-0 3-amino-1-(4-methoxybenzyl)-2-pyridone 

Relevant articles and documents

3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP 3 receptor antagonists

A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP3 antagonists via high-throughput screening and subsequent optimization. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in potent and selective EP3 receptor antagonists such as 11g are described.

Preparation of novel heteroisoindoles from nitropyridines and nitropyridones

The reaction of nitropyridine derivatives with ethyl isocyanoacetate in the presence of 1,8-diazabicyclo[5.4.0]undecene proceeded tandem cyclization to give polycyclic pyrrolopyridines or imidazopyridines. On the other hand, N-protected 3-nitro- and 5-nitropyridones and N,N-diprotected 5-nitrouracil gave corresponding bicyclic pyrroles in good yields under the similar conditions.