356578-32-0Relevant academic research and scientific papers
3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP 3 receptor antagonists
Li, Yue H.,Tseng, Pei-San,Evans, Karen A.,Jaworski, Jon-Paul,Morrow, Dwight M.,Fries, Harvey E.,Wu, Charlene W.,Edwards, Richard M.,Jin, Jian
scheme or table, p. 6744 - 6747 (2010/12/20)
A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP3 antagonists via high-throughput screening and subsequent optimization. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in potent and selective EP3 receptor antagonists such as 11g are described.
Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain
Proudfoot,Betageri,Cardozo,Gilmore,Glynn,Hickey,Jakes,Kabcenell,Kirrane,Tibolla,Lukas,Patel,Sharma,Yazdanian,Moss,Beaulieu,Cameron,Ferland,Gauthier,Gillard,Gorys,Poirier,Rancourt,Wernic,Montse
, p. 2421 - 2431 (2007/10/03)
p56lck is a member of the src family of tyrosine kinases and plays a critical role in the signal transduction events that lead to T cell activation. Ligands for the p56lck SH2 domain have the potential to disrupt the interaction of p56lck with its substra
