35674-14-7

Usage

Uses

Used in Pharmaceutical Industry:
6,1',6'-tri-O-tribenzylsucrose is used as an intermediate in the synthesis of various sucrose derivatives, which have potential applications in the pharmaceutical industry. These derivatives can be used as active ingredients in the development of new drugs or as additives to improve the properties of existing medications.
Used in Chemical Synthesis:
6,1',6'-tri-O-tribenzylsucrose serves as a valuable building block in organic chemistry, particularly in the synthesis of complex organic molecules. Its unique structure allows for selective functionalization and modification, making it a useful starting material for the preparation of a wide range of compounds.
Used in Bacteriostatic Applications:
6,1',6'-tri-O-tribenzylsucrose is used as a key component in the preparation of sucrose derivatives with bacteriostatic properties. These derivatives can be employed as additives in various industries, such as food and pharmaceuticals, to inhibit the growth of bacteria and extend the shelf life of products.

Upstream product

• 76-83-5 trityl chloride 
• 57-50-1 Sucrose 

Downstream Products

• 131508-67-3 Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-[(R)-2-acetoxy-1-((R)-1-acetoxymethyl-2-trityloxy-ethoxy)-ethoxy]-2,5-bis-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 129720-60-1 Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-[(R)-2-acetoxy-1-((1R,2S)-2,3-diacetoxy-1-trityloxymethyl-propoxy)-ethoxy]-2,5-bis-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 105165-70-6 2-O-tosyl-6,1',6'-tri-O-tritylsucrose 
• 35674-02-3 2,3,3',4,4'-penta-O-methyl-1',6,6'-tri-O-tritylsucrose 
• 35674-16-9 2,3,4,3',4'-penta-O-benzoyl-6,1',6'-tri-O-tritylsucrose 
• 111829-03-9 6-O-trityl-α-D-glucopyranosyl 3,4-anhydro-1,6-di-O-trityl-β-D-lyxo-hexulofuranoside 
• 111829-04-0 3,4-anhydro-1,6-di-O-trityl-β-D-lyxo-hexulofuranosyl 2,3,4-tri-O-acetyl-6-O-trityl-α-D-glucopyranoside 
• 35867-26-6 2,3,4,3',4'-penta-O-acetyl-6,1',6'-tri-O-tritylsucrose 
• 105165-77-3 2,4-di-O-acetyl-3-S-(N,N-dimethylaminothiocarbonyl)-3-thio-6-O-trityl-α-D-altropyranosyl 3,4-di-O-acetyl-1,6-di-O-trityl-β-D-fructofuranoside 
• 105165-78-4 2,4-di-O-acetyl-3-S-acetyl-3-thio-6-O-trityl-α-D-altropyranosyl 3,4-di-O-acetyl-1,6-di-O-trityl-β-D-fructofuranoside 
• 105165-82-0 Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-((2R,3R,4S,5R,6R)-3,5-diacetoxy-4-iodo-6-trityloxymethyl-tetrahydro-pyran-2-yloxy)-2,5-bis-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 105165-75-1 Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-((1R,2R,4R,5S,6R)-5-acetoxy-2-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]hept-4-yloxy)-2,5-bis-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 105165-80-8 4-O-acetyl-2,3-epithio-6-O-trityl-α-D-allopyranosyl-3,4-di-O-acetyl-1,6-di-O-trityl-β-D-fructofuranoside 
• 105165-73-9 Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-((1S,2R,4R,5R,6S)-5-acetoxy-4-trityloxymethyl-3,7-dioxa-bicyclo[4.1.0]hept-2-yloxy)-2,5-bis-trityloxymethyl-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Process to Prepare Sucralose

The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1)

METHOD OF PRODUCING SUCRALOSE

A method of producing sucralose is disclosed. The method of producing sucralose comprises the steps of preparing a compound (6, 1', 6'-tri- 0 -tritylsucrosepenta- acetate) by reacting sucrose, which is a starting material, with a tritylating agent to form a reaction product, and then reacting the reaction product with acetic anhydride (step 1); preparing a compound (2, 3, 4, 3', 4'-penta- 0 -acetylsucrose) by reacting the compound prepared in step 1 with hydrogen chloride gas having the same equivalent amount as the compound (step 2); preparing a compound (2, 3, 6, 3', 4'-penta- 0 -acetylsucrose) by isomerizing the compound prepared in step 2, under a base catalyst (step 3); preparing a compound (4, 1', 6'-trichloro- 4, 1', 6'-trideoxy-2, 3, 6, 3', 4'-penta- 0 -acetyl-galactosucrose) by chlorinating the compound prepared in step 3 (step 4); and preparing 4,1, 6'-trichloro-4, 1', 6'-trideoxygalactosucrose by deacetylating the compound prepared in step 4, and then filtering the deacetylated compound using a cation exchange resin (step 5).

Novel chlorination process for preparing sucralose

A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose from sucrose-6-esters are provided.

PROCESS FOR THE PREPARATION OF A GLUCOSE DERIVATIVE

The present invention relates to an improved, safe, commercially viable, cost effective and eco friendly process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (Sucralose). The invention is directed towards the convenient synthesis of 2,3,4,3',4'-penta-O-acetyl sucrose (4-PAS) from 6,1',6'-tri-O-trityl-penta-O-acetyl sucrose ("TRISPA").

SYNTHESIS OF 6,6'-DIDEOXY-6,6'-DIFLUOROSUCROSE

The chemical synthesis of 6,6'-dideoxy-6,6'-difluorosucrose was accomplished in five steps: (a) tritylation of C-6,1' and -6' of sucrose; (b) benzoylation of 6,1',6'-tri-O-tritylsucrose; (c) detritylation with mild acid; (d) fluorination at C-6 and -6' with diethylaminosulfur trifluoride (DAST); and (e) debenzoylation.The resulting compound was chromatographically pure.The structure was established by (13)C and (19)F-n.m.r. spectrometry and by elemental analysis.