35676-71-2

Usage

Bicyclic heterocyclic compound

quinoxalinone derivative

Substitution

3-methoxy group added to the quinoxalinone ring

Potential applications

medicinal chemistry, pharmaceutical research, drug discovery and development

Properties

interesting pharmacological and biological properties

Usage

building block for the synthesis of more complex organic molecules

Unique structure

makes it an interesting target for further study

Upstream product

• 32998-25-7 2-chloro-3-methoxyquinoxaline 
• 15804-19-0 quinoxaline-2,3-dione 
• 18370-95-1 methyl 2,2,2-trimethoxyacetate 
• 95-54-5 1,2-diamino-benzene 
• 67-56-1 methanol 
• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 2213-63-0 2,3-dichloroquinoxaline 

Relevant academic research and scientific papers

Synthesis of 3-methoxy-quinoxalin-2-ones from methyl trimethoxyacetate and phenylenediamines

Treatment of phenylenediamines with methyl trimethoxyacetate led to the formation of 3-methoxy-quinoxalin-2-ones with the assistance of lanthanide-based Lewis acids.

PIDA-induced oxidative C–N bond coupling of quinoxalinones and azoles

A metal-free promoted direct oxidative C–N bond coupling of quinoxalinones and azoles for the rapid and effective synthesis of potent pharmaceutical important 3-(azol-1-yl)quinoxalin-2-one has been developed. Employing PIDA as the easily available mediator, the desired coupling products were isolated in moderate to excellent yields with a good substrate scope under operational simplicity and mild reaction conditions. Preliminary mechanistic studies suggested that a radical process is likely to be involved in the reaction.

Quinoxaline compounds

Quinoxaline compounds, compositions, methods of making them, and methods of using them in leukocyte recruitment inhibition, in modulating an H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.